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NIH funding notice PA-22-178

PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

Closed on April 5, 2023.

Posted
June 2, 2022
Close date
April 5, 2023
Activity codes
R41, R42
Institutes taking part
OD, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH, NCATS, NCI, ORIP

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-21-262 PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  2. 2 steps back: PA-20-265 PHS 2020-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  3. 3 steps back: PA-19-270 PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed
  4. 4 steps back: PA-18-575 PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  5. 5 steps back: PA-17-303 PHS 2017-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  6. 6 steps back: PA-16-303 PHS 2016-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  7. 7 steps back: PA-15-270 PHS 2015-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  8. 8 steps back: PA-14-072 PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]
  9. 9 steps back: PA-13-235 Reissue PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  10. 10 steps back: PA-13-089 PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  11. 11 steps back: PA-12-089 PHS 2012-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  12. 12 steps back: PA-11-097 PHS 2011-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  13. 13 steps back: PA-10-051 PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
  14. 14 steps back: PA-09-081 PHS 2009-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])

Replaced by PA-23-232.

Who won it before

1,925 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $657,676,719 in first-year total cost, median $273,556.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 SBIB-T (10)]101
  2. Special Emphasis Panel[ZRG1 OTC-T (10)]81
  3. Special Emphasis Panel[ZRG1 ETTN-G (12)]62
  4. Special Emphasis Panel[ZRG1 ETTN-M (11)]55
  5. Special Emphasis Panel[ZRG1 BCMB-G (10)]52

Most frequent institutions

  1. FOX CHASE CHEMICAL DIVERSITY CENTER, INC19
  2. L2 DIAGNOSTICS, LLC13
  3. MEDOSOME BIOTEC, LLC10
  4. ARREVUS, INC.8
  5. KLEIN BUENDEL, INC.8
Competing awards under PA-22-178 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2024Development of a Peptide-Drug Conjugate for Topically Treating the Viral Skin Disease Molluscum Contagiosum2R42AI162385-03RICCIARDI, ROBERT PAULFOX CHASE CHEMICAL DIVERSITY CENTER, INC, PA$1,039,551ZRG1
2024A New Small-Molecule Kinase Inhibitor for Airway Disease2R42HL149523-02BROSCHAT, KAY ONUPEAK THERAPEUTICS, INC., MO$1,018,383ZRG1
2024Prevention of corneal transplant rejection using AAV-BDRK-401 therapy2R42EY031625-02GILGER, BRIAN CHIRSCH, MATTHEW LOUISBEDROCK THERAPEUTICS, INC., NC$975,387ZRG1
2024A New Anti-inflammatory Therapy for Ischemic Stroke2R42HL156322-02A1LIANG, BRUCECORNOVUS PHARMACEUTICALS, INC., CT$934,548ZRG1
2024Development of an integrated smartphone-nanosensor platform for onsite biomonitoring of exposure to pesticides2R42ES032388-02A1WANG, JUNNANODIAGNOSTIC TECHNOLOGY, LLC, NC$915,031ZRG1
2024Automated microfluidic device for blood analysis in neonates2R42HD100251-02GONZALEZ-SUAREZ, ALAN MSERSENSE, INC., MN$780,138ZRG1
2024Development of a Novel AAV9 Gene Replacement Therapy for Neurofibromatosis Type 21R41NS135883-01HENWOOD, NICOLENAEIMI KARAROUDI, MEISAMMERLIN THERAPEUTICS INC, PA$699,559ZRG1
2024STTR Phase II - Development of a visual-to-tactile conversion system for automating the tactile graphic generation process2R42EY031628-02A1PALANI, HARI PRASATHUNAR LABS, LLC, ME$674,598ZRG1
2024Novel brain-penetrant drugs for translation-targeting therapeutics of Alzheimer’s disease1R41AG085859-01CHEN, XIANTRANSCHROMIX, LLC., NC$497,218ZRG1
2024Single telomere length analysis using DNA array and FISH: a low-cost and accurate test for telomere-associated diseases1R41AG085701-01WANG, YINGZHENG, YUN-LINGTELOHEALTHDX LLC, MD$448,961ZRG1
2024Preventing chemotherapy-related toxicities and infections with a novel phosphorylated triblock copolymer1R41CA287593-01ALVERDY, JOHN CHENNESSEY, PATRICKCOVIRA SURGICAL, IL$400,000ZRG1
2024Stroma-penetrating nanomedicine to improve treatment for pancreatic cancer1R41CA278033-01A1EICHINGER, KATHERINE MARIEDUO ONCOLOGY INC, PA$399,970ZRG1
2024Multi-Modality Optical Molecular Imaging System for Preclinical Cancer Models1R42CA287798-01GULSEN, GULTEKINMOY, AUSTINTRIFOIL IMAGING, CA$399,491ZRG1
2024Innovative Point-of-Care Solutions for Long-term Alcohol Biomarkers1R41AA031429-01NEILSEN, PAUL OECHELON BIOSCIENCES, INC., UT$399,293ZRG1
2024Antibody-based prertargeted alpha particle therapy for ovarian cancer1R42CA287696-01HOUGHTON, JACOBSCHULTZ, MICHAEL KINGVIEWPOINT MOLECULAR TARGETING, INC., IA$391,553ZRG1
2024Development of a mobile harm reduction treatment for alcohol use disorder (mHaRT-A)1R41AA031393-01COLLINS, SUSAN EHART3S - A SOCIAL PURPOSE CORPORATION, WA$369,597ZRG1
2024Tethered Enzyme Technology for PoC and At-home Real-time Monitoring of Liver Function1R41TR004880-01COHEN, ROYFISCHELL, DAVIDTET MEDICAL, NY$324,962ZRG1
2024Novel Integrated Platform to Quantitate Rejuvenation in vivo1R41AG085951-01EGAN, BRIAN STANLEYJELINEK, MARY ANNETERSKIKH, ALEXEY VACTIVE MOTIF, INC., CA$314,262ZRG1
2024Rapid Dehydration and Stabilization of Biopharmaceutical Formulations at Room Temperature1R41TR004571-01A1MEZHERICHER, MAKSIMINAEDIS, INC, NJ$312,634ZRG1
2024Computational design and evaluation of peptide-guided protein degraders1R41GM153081-01CAMARGO, LUIZ MIGUEL QUINNUBIQUITX, INC., NY$306,872ZRG1
2024Development of Small Molecule Biomarker-Based Diagnostics for Bacterial Vaginosis1R41AI176963-01A1SRINIVASAN, SUJATHAMETABOLITEDX CORP, WA$306,500ZRG1
2024Innovative oral regenerative therapy leveraging immunoregenerative mechanisms.1R41DE033573-01GOUDY, STEVEN LORIDIVUS LLC, GA$306,499ZRG1
2024Multi-functional magnetic nanorods for constructing theranostic extracellular vesicles for treating myocardial infarction1R41HL169102-01A1LI, YUANCHENGLIU, GUANSHU5M BIOMED, LLC, GA$306,433ZRG1
2024Epigenetic phenotyping from liquid biopsy for preeclampsia risk classification during the first trimester1R41HL172464-01REICHEL, JONATHANKANONA, INC., NJ$306,223ZRG1
2024Multi-omic CSF Assay for the Diagnosis of Brain Cancers1R42NS135834-01BETTEGOWDA, CHETANCOE, BRIANBELAY DIAGNOSTICS, LLC, IL$303,845ZRG1
2024Chimeric antigen receptor (CAR) T cell therapy for severe allergic diseases.1R41AI177157-01A1MA, ZHENGYUCELLERGY PHARMA, DE$300,000ZRG1
2024Development of Inhibitors Against SARS CoV-2 NSP16 Methyltransferase1R41AI177149-01A1LI, HONGMINLYCHEE BIOSCIENCE LLC, AZ$299,985ZRG1
2024Development of a Pan-COVID-19 Vaccine Candidate1R41AI181134-01HU, HAITAORNA THERAPEUTICS INC., DE$299,967ZRG1
2024Develop natural compound emodin as a novel therapy for calcific aortic valve disease1R41HL172481-01AZHAR, MOHAMADACEPRE, LLC, SC$299,953ZRG1
2024A Biosinpired Genetically-Expressible Dual-Modality Peptide-Based Probe for Super-Resolution Correlative Light and Electron Microscopy1R41GM153173-01LAWRENCE, CHARLES MARTINLEWIS, KEVIN MICHAELPHOTON BIOSCIENCES, LLC, WA$299,812ZRG1
2024MECHANICALLY ROBUST 3D-PRINTED MICROCAPILLARY NEEDLES WITH ANTI-CLOGGING CAPABILITIES1R41GM153053-01RAND, KINNERETSEETRUE TECHNOLOGY, LLC, MD$296,043ZRG1
2024RHODA: Rapid Hemoglobin-Oxygen Dissociation Assay1R41HL172662-01GALEN, PETERGURKAN, UMUT A.HEMEX HEALTH, INC., OR$295,920ZRG1
2024Feasibility of Electronic Screening to Identify Risk of Opioid Misuse and Overdose1R41DA060000-01FERRARESE, NICKOPREMS LLC, IL$295,876ZRG1
2024Evaluation of siRNA based drugs as pro-regenerative disease-modifying therapeutics for age-related olfactory loss1R41DC021592-01SCHWOB, JAMES E.WYNNE, GRAHAM MICHAELRHINO THERAPEUTICS INC, DE$295,662ZRG1
2024Antigen and adjuvant selection for a vaccine against urogenital schistosomiasis, Hematoshield1R41AI181069-01GRAY, SEAN ALEXMOLEHIN, ADEBAYO JPAI LIFE SCIENCES, INC., WA$295,386ZRG1
2024Low-Cost Ultrasound Imaging for In-Home, Rural, and Clinic Care Without The Need For Trained Staff1R41EB034646-01A1DAHL, JEREMYRAGHAVAN, RAGHUSONOVANCE, INC., MD$294,641ZRG1
2024Developing novel Type 1 CRISPR tools for gene editing therapy1R41GM153041-01HOU, ZHONGGANGGENETOBE INC., MI$293,319ZRG1
2024Targeting retinoid acid metabolic pathways to treat noise-induced hearing loss1R41DC021394-01DIAZ, PHILIPPE JDERMAXON, LLC, MT$290,920ZRG1
2024MyDocSaid: Deep Learning for Patient-Centric Record, Summarization, and Analysis of Medical Conversations1R41NR021089-01MARHAMATI, NINAPOTENTIA ANALYTICS INC, IL$284,317ZRG1
2024Personal Cooling Garments to Protect at-Risk Patients from Extreme Heat Waves1R41HL172682-01IHNFELDT, ROBINGENERAL ENGINEERING AND RESEARCH, LLC, CA$275,765ZRG1
2024Development and in vivo validation of a machine learning platform to predict ototoxic potential of pharmaceuticals1R41DC021390-01HARKNESS, JOHN HREWIRE NEUROSCIENCE, LLC, OR$275,737ZRG1
2024Safety of AAV-mediated C1 Esterase Inhibitor Gene Therapy for Hereditary Angioedema1R41AI181097-01CRYSTAL, RONALD GENYX THERAPEUTICS, LLC, NY$275,737ZRG1
2024Focal seizure monitoring with a consumer wearable: algorithmic development and validation1R41NS130958-01 · under PA-21-262CRONE, NATHAN EEPIWATCH, INC., MD$275,547ZRG1
2024Combating Corneal HSV Infection with Novel Dynasore Analogues1R41EY035879-01LAZAROVA, TSVETELINA IVANONOVAST LEGER, ANTHONY JMEDCHEM PARTNERS, LLC, MA$180,642ZRG1
2024Developing a therapeutic, music-based mobile application to combat neuropsychiatric symptoms in people living with Alzheimer's disease and related dementias1R41AT012152-01A1ATASHZAR, SEYED FAROKHRAY, KENDRAAUTOTUNE ME LLC, NY$71,980ZRG1
2023Chemical-based Nitric Oxide Gas-generating Drug Device for the Treatment of Pulmonary Hypertension2R42HL152921-02A1 · under PA-21-262LESSING, GARYINOVODEL, INC., DE$1,467,953ZRG1
2023Optimizing Radiosynthetic Yield of [18F]FTT For Wide-Spread Distribution2R42CA261259-02A1LEE, HSIAOJU SHARONMIKHAIL, MICHELTREVARX BIOMEDICAL, INC., PA$1,043,889ZRG1
2023Selective targeting of high affinity alpha4 integrins as a safe treatment strategy for IBD2R42DK127869-02A1BIEDIGER, RONALD JHOLLAND, GEORGEWOODSIDE, DARREN GAVIARA PHARMACEUTICALS, INC., TX$1,036,641ZRG1
2023Development of a Wearable Fluorescence Imaging Device for IntraoperativeIdentification of Brain Tumors2R42CA243600-02YU, GUOQIANGBIOPTICSTECHNOLOGY, LLC, KY$1,027,934ZRG1
2023The Rapid-Production of the High-Performance and Affordable Cadmium Telluride and Cadmium Zinc Telluride for Medical Imaging Applications.2R44EB029280-02A1FURENLID, LARS RMCCLOY, JOHN SMONTAG, BENJAMINSWAIN, SANTOSH KUMARRADIATION DETECTION TECHNOLOGIES, INC., KS$1,024,886ZRG1
2023A human monoclonal antibody therapy for treatment of hantavirus cardiopulmonary syndrome2R42AI132047-03 · under PA-21-262BOTTEN, JASON W.MURAD, JOANA MCELDARA MEDICAL, LLC, NH$1,000,000ZRG1
2023Treatment of Inflammatory Complications of Respiratory Infection2R42AI162590-02PELURA, TIMOTHY JRESPANA THERAPEUTICS, INC., PA$1,000,000ZRG1
2023Programming Metabolically Fit TILs for Immunotherapy2R42CA239952-02MEHROTRA, SHIKHARLIPO-IMMUNO TECH, LLC, SC$1,000,000ZRG1
2023Lipid Receptor GPR31 as a Target for Anti-Thrombotic and Stroke Therapy2R42HL160429-02 · under PA-21-262KULIOPULOS, ATHANOASIS PHARMACEUTICALS, MA$999,799ZRG1
2023Real-time Multimodal Diffuse Reflectance and Polarization Imaging Based Nerve Identification in Surgical Field of View2R42EB029888-02BABA, JUSTINYAYA SCIENTIFIC, LLC, TN$998,991ZRG1
2023SensiTrak: Automated Assessment of Forelimb Sensation2R44NS120748-02 · under PA-21-262SANCHEZ, CAMILO ANDRESVULINTUS, LLC, TX$982,150ZRG1
2023Improved Treatment of Colorectal Cancer with CF102R42CA254834-02A1GMEINER, WILLIAM H.DEEP CREEK PHARMA, LLC, NC$964,465ZRG1
2023Enabling Next Generation Machine Learning for Large Scale Image Analysis2R44EB032722-02A1SABIN, GERALDRNET TECHNOLOGIES, INC., OH$937,441ZRG1
2023Implantable Microarray Probe for Real-Time Glutamate and GABA Detection2R42NS115282-02A1ARUMUGAM, PRABHUMOLDOVAN, NICOLAIE ANDREIVETTER, RIO JALCORIX, IL$903,957ZRG1
2023Controlled-release Microbeads to Replace Growth Factors in Fetal Bovine Serum2R42GM142345-02 · under PA-21-262ROBERTS, KRISTINASTERN, JEFFREY HSTEMCULTURES, LLC, NY$903,045ZRG1
2023A dual-acting small molecule for the treatment of type 1 diabetes2R42DK131839-02A1NUNEMAKER, CRAIG SWU, SHIYONGASAKE BIOTECHNOLOGY, LLC, OH$609,183ZRG1
2023A non-invasive, automated platform for hemodynamic assessment of patients at risk of heart failure or pulmonary hypertension1R42HL167342-01A1ARNOLD, ANTHONYMAHAJAN, AMANSENSYDIA CORPORATION, CA$605,537ZRG1
2023Addressing the wireless power problem: A low-power hybrid radio for neuroscience experiments1R43MH135814-01GERTH, REBECCA JEANNEMORIZIO, JAMESSPIKE NEURO LLC, MI$567,282ZRG1
2023CN-105 Improves Functional Outcome After Intracranial Hemorrhage2R42NS108821-02A1BENNETT, ELLENAEGISCN, LLC, NC$562,291ZRG1
2023Development of a Biomimetic Stentless Pulmonary Heart Valve for the Treatment of Pediatric Congenital Heart Disease1R41HL167502-01A1COYAN, GARRETT ND'AMORE, ANTONIONEOOLIFE, INC., PA$553,838ZRG1
2023Two-for-one Stroke Thrombectomy: A novel Dual DAC to enhance navigability, lumen size, aspiration efficiency, and persistent flow arrest in mechanical thrombectomy1R41NS129448-01A1KALLMES, DAVID FPIRAEUS MEDICAL, INC., MN$499,765ZRG1
2023High density chronic optogenetic interface for primate brains1R44MH135529-01A1ANGELUCCI, ALESSANDRABLAIR, STEVEN MMATHIESON, KEITHNEGI, SANDEEPRIETH, LORENBLACKROCK MICROSYSTEMS, UT$496,413ZRG1
2023Restoration of Muscular Function Following Direct Muscle Neurotization1R41NS132734-01SOLETTI, LORENZORENERVA, LLC, PA$494,955ZRG1
2023Targeted ColQ gene therapy for Congenital Myasthenic Syndromes1R42NS127713-01A1 · under PA-21-262MASELLI, RICARDO ANIBALSEPULVEDA, PATRICIOAMPLO BIOTECHNOLOGY, INC., MD$493,111ZRG1
2023Testing the effects of a selective calpain-2 inhibitor on spontaneous recurrent seizures in mouse models of epilepsy1R41NS130825-01A1BAUDRY, MICHELBI, XIAONINGNEURAEGIS, INC., CA$489,268ZRG1
2023Inducible HMGB1 antagonist for viral-induced acute lung injury.1R41HL167254-01 · under PA-21-262BLANCO, JORGE CVOGEL, STEFANIE N.SIGMOVIR BIOSYSTEMS, INC., MD$488,080ZRG1
2023IND-enabling studies for cell therapy in Parkinson's disease1R41NS132678-01A1DAADI, MARCELNEONEURON, LLC, TX$465,228ZRG1
2023Development of Novel Small Molecule Anti-Fibrotic Agent for the Treatment of Systemic Scleroderma1R41HL167548-01 · under PA-21-262ALEGRIA, ESTHER MAPIE THERAPEUTICS, INC., NC$452,422ZRG1
2023Evaluation of growth potential of ice-free vitrified heart valves in a pediatric porcine model.1R41HL169059-01RAJAB, TAUFIEK KONRADTISSUE TESTING TECHNOLOGIES, LLC, SC$452,184ZRG1
2023Live spike sorting for multichannel and high-channel recordings1R41NS132700-01A1KLUG, ACHIMLEI, TIM CHIFONGPOPNEURON LLC, CO$438,501ZRG1
2023Developing a selective TRPC3 ion channel inhibitor for epilepsy treatment1R41NS135658-01LI, WEISEAK THERAPEUTICS, LLC, TN$429,932ZRG1
2023Aerosolized Chemically Modified Tetracycline Nanoformulation for the Treatment of Acute Respiratory Distress Syndrome1R42HL166050-01A1 · under PA-21-262KOLLISCH-SINGULE, MICHAELA CHRISTINALUO, JUNTAOCMTX BIOTECH, INC., NY$426,744ZRG1
2023Optical gearbox enabled high-speed multiphoton microscope1R43MH135716-01CUI, MENGWU, TSAIWEIPHOTOMATRIX, IN$425,958ZRG1
2023Controlled Gradient Release of Biologics: Enhanced Nerve Conduit for Long‐Gap Injury Repair1R41NS130907-01 · under PA-21-262ROMERO-ORTEGA, MARIO IGNACIOPIONEER NEUROTECH INC., MA$422,015ZRG1
2023Developing novel LOX inhibitors to target chemotherapy resistant TNBC1R42CA275622-01A1SAHIN, OZGURLOXIGEN, INC., SC$406,500ZRG1
2023MT-125 for the Therapeutic Treatment of Glioblastoma1R42CA278293-01A1ROSENFELD, STEVEN SMYOSIN THERAPEUTICS INC., FL$406,500ZRG1
2023Neural organoid models of the immunological microenvironment of glioblastoma for drug discovery applications1R41CA281533-01A1LEBAKKEN, CONNIE SSTEM PHARM, INC., WI$406,500ZRG1
2023Light-directed therapy of squamous cell head and neck cancer with a novel dual-acting chemotherapeutic.1R41CA281440-01A1HARADA, HISASHIHARTMAN, MATTHEW CLIGHT SWITCH BIO, LLC, VA$406,186ZRG1
2023Image-based risk assessment to identify women at high-risk for breast cancer1R41CA285182-01KHALIL, ANDREWAVED MEDICAL LLC, ME$405,950ZRG1
20233D microprinting-enabled microinjection needle arrays for enhanced therapeutics delivery into the brain1R41MH135827-01RAND, KINNERETSEETRUE TECHNOLOGY, LLC, MD$403,847ZRG1
2023A decellularized porcine placenta matrix hydrogel for management of radiation-induced proctitis1R41CA272043-01A1 · under PA-21-262LI, JIAN JIANBRIOPRYME BIOLOGICS, INC., CA$400,000ZRG1
2023Development of drug conjugates of R-spondin peptibodies for the treatment of colorectal cancer1R41CA281553-01CUI, JIELIU, QINGYUNWNTRIX, INC., TX$400,000ZRG1
2023Targeting glioblastoma with CM93, a novel EGFR inhibitor with exceptional brain penetration1R41CA281586-01ZHAO, JEANCRIMSON BIOPHARM INC, MA$400,000ZRG1
2023Novel Drug Delivery Platform as Medical Countermeasure for treatment of Gastrointestinal Radiation Damage1R41CA272078-01A1MARSH, SPENCER REIDTINY CARGO COMPANY, THE, VA$400,000ZRG1
2023Tumor Antigen Targeted Nanoparticle Therapy for Glioblastoma (GBM)1R42CA281707-01NAGY, JON OWENTRICHE, TIMOTHY J.NANOVALENT PHARMACEUTICALS, INC., MT$400,000ZRG1
2023Extended half-life GlyTR1 combined with checkpoint blockade for Cancer Immunotherapy1R42CA285234-01DEMETRIOU, MICHAELZHOU, RAYMOND WENHOUGLYTR THERAPEUTICS, INC., CA$400,000ZRG1
2023Genetic Biocontainment Switch to Improve the Safety of Drug Detoxifying Bacteria in Preventing Chemotherapy-induced Diarrhea1R41CA275454-01A1CHAN, TSZ YAN CLEMENTHU, MINGSINGH, RASHIMSANARENTERO LLC, TX$399,999ZRG1
2023A Novel Melanoma Vaccine Based on a Shared Neoantigen and a Liquid Polymer Platform1R41CA278184-01A1BLOCK, MATTHEW STEPHENWANG, CHUNTREKKA THERAPEUTICS, LLC, MN$399,979ZRG1
2023GENOMICE (Game Exploring Nuances in Offspring to Master Interactions of Chromosome Expression)1R41HG013076-01A1AARON, ERICFREEDMAN, RICHARD GABRIELTILDEN, ANDREA RSMART INFORMATION FLOW TECHNOLOGIES, MN$399,948ZRG1
2023Human specific STING agonists for the treatment of cancer1R41CA275637-01A1AHN, JEONGHYUNBARBER, GLEN NSTINGINN, LLC, FL$399,812ZRG1
2023Water-based liquid embolic agent for the treatment of vascular rich tumors1R41CA277860-01A1YUKI, ICHIROAQUATEX MEDICAL, INC., CA$399,528ZRG1
2023An IGF-1R-targeting peptide drug conjugate for targeted treatment of atypical teratoid/rhabdoid tumors1R41CA285172-01GOLDSTEIN, NEILNIGHTHAWK BIOSCIENCES, INC., NC$399,110ZRG1
2023Synergize a novel homologous recombination inhibitor with DNA damagingagents in TNBC1R41CA281511-01A1NEUMANN, CAROLA ANKESCHOPFER, FRANCISCO JOSECREEGH PHARMACEUTICALS, INC., PA$398,728ZRG1
2023Preclinical Evaluation of a Novel ADAM10 Modulator to Treat ColorectalCancer1R41CA278070-01A1PREMSRIRUT, PREM KHOVABUTRMIRIMUS, INC., NY$397,916ZRG1
2023Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Crohn's disease1R41DK138578-01SCHULTZ, KENNETHTRETHERA CORPORATION, CA$395,119ZRG1
2023A novel dual-carrier ultrasmall nanomedicine for the treatment of stroma-rich pancreatic cancer1R41CA285174-01EICHINGER, KATHERINE MARIEDUO ONCOLOGY INC, PA$394,967ZRG1
2023Therapeutic targeting of FKBP51 for the prevention of stress-induced preterm birth1R41HD113465-01FRIEND, DAVID RDARE BIOSCIENCE, INC., CA$384,972ZRG1
2023Closed-loop laryngeal pacing for voice restoration1R41DC020869-01A1HEATON, JAMES T.HIATT, SCOTTRIPPLE, LLC, UT$382,366ZRG1
2023A Novel Therapeutic to Promote Corneal Repair1R42EY034791-01A1CHUCK, ROY SKRAMER, ADAM HILDYARDSHARP, DAVID JAMESMICROCURES, INC., CA$380,000ZRG1
2023Towards intra-operative guidance in brain tumor surgery using real-time resting-state functional MRI1R42NS134505-01DENNIG, DIETER WPOSSE, STEFANNEURINSIGHT, LLC, NM$378,233ZRG1
2023Novel Small Molecule Drug Candidate for the Prevention of Bronchopulmonary Dysplasia1R41HD112274-01KOLLISCH-SINGULE, MICHAELA CHRISTINACMTX BIOTECH, INC., NY$376,752ZRG1
2023THERAPY FOR ALCOHOL USE DISORDER1R41AA031392-01SELTZMAN, HERBERT HARTIAM BIO INC., NC$368,673ZRG1
2023Endoscopy-assisted intracochlear access via ultrasharp-microneedles1R41DC021128-01AKSIT, AYKUTLALWANI, ANIL KHAYSTACK MEDICAL, INC., NY$350,033ZRG1
2023Nanopore Array for Multiparameter Analysis of Single Extracellular Vesicles1R41GM151921-01GERMAN, SEANELECTRONIC BIOSCIENCES, INC., CA$349,996ZRG1
2023Prodrugs of potent and selective protease inhibitors as tauopathy therapeutics1R41NS134497-01ASHE, KAREN HWALTERS, MICHAEL A.MYRIEL, INC., MN$349,992ZRG1
2023Sulfated Carbohydrates for the Treatment of Periodontitis1R41DE032276-01A1MIGUEZ, PATRICIAGLYCAN THERAPEUTICS CORPORATION, NC$347,537ZRG1
2023MTI-301 a SCD1 inhibitor for the treatment of NASH1R41DK131705-01A1GELDENHUYS, WERNERHAZLEHURST, LORIMODULATION THERAPEUTICS, INC., WV$344,919ZRG1
2023Rusalatide Acetate (TP508) Mitigation Effect on Radiation Induced Keratopathy1R41EY034773-01 · under PA-21-262ANDLEY, USHA PHAMRAH, PEDRAMAFFIRMED PHARMA, LLC, TX$341,302ZRG1
2023Novel Highly Regenerative and Scalable Progenitor Cell Exosomes for Treating Peripheral Artery Disease1R41HL170875-01HUANG, NGAN F.LEE, JI EUNSERINA THERAPEUTICS, INC., CA$340,956ZRG1
2023Improving parent-adolescent communication about sexual and reproductive health1R41HD112212-01A1WIDMAN, LAURA M.TEEN HEALTH RESEARCH, INC., NC$340,143ZRG1
2023A novel producer cell line for more efficient manufacturing of viral vector systems1R41TR004231-01A1 · under PA-21-262HAMM, ELAINECLAIRIGENE, LLC, NC$330,532ZRG1
2023CRISPR-Cas Editing as a Genetic Cure for Autosomal Dominant Polycystic Kidney Disease1R41DK138689-01MAXIM, DEMETRIOS STHAKOR, AVNESH SINHNEPHROGEN INC., NY$325,000ZRG1
2023Exploiting translation elongation for improved biologics manufacturing1R41TR004774-01BYRNE, SHANEDEDON, PETER CCODOMAX INC., MA$324,999ZRG1
2023A novel platform for synthetic generation and statistical obfuscation of tabular clinical data, simulated images, and machine-generated text1R41TR004515-01SHETTY, RONAKGRAYRAIN, LLC, MI$324,632ZRG1
2023The development of the Clinical Picture Maker, a novel video platform to aid the diagnosis and treatment of SCN2A-related disorders, and other rare diseases.1R41TR004790-01TIRANOFF, LOUISE MARYTIRANOFF PRODUCTIONS, LLC, NY$321,945ZRG1
2023Leptin Receptor Agonist to Treat Sleep Disordered Breathing1R41HL167326-01 · under PA-21-262KRAUS, CARL NEILPOLOTSKY, VSEVOLOD YARREVUS, INC., NC$319,944ZRG1
2023Using in-vivo Real-time Biosensor to Evaluate Prodrugs Designed to Prolong Therapeutic Effects for Smoking Cessation.1R41DA056334-01A1 · under PA-21-262BETLEY, JOHN NICHOLASLEE, PETER HSPACERX LLC, VA$318,605ZRG1
2023Evaluation of recombinant bovine lactoferrin and N-linked glycan effects on infant gut health and immunity1R41HD114267-01FEHER CASTAGNA, VANESSA PATRICIAJIANG, RULANTURTLETREE LABS INC., CA$311,323ZRG1
2023Development of a treatment for durable remission of HIV using transposon engineered CAR-T and NK cells1R41AI170186-01A1 · under PA-21-262ATHANASIOU, MARIA CONSTANCESKINNER, PAMELA JMARPAM PHARMA, LLC, MN$306,500ZRG1
2023Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Systemic Lupus Erythematosus1R41AI179213-01SCHULTZ, KENNETHTRETHERA CORPORATION, CA$305,135ZRG1
2023Development of a Diagnostic Test for Eosinophilic Chronic Rhinosinusitis1R41AI179525-01PULSIPHER, ABIGAILGLYCOMIRA, LLC, UT$304,921ZRG1
2023Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Acute Disseminated Encephalomyelitis (ADEM)1R41AI179191-01SCHULTZ, KENNETHTRETHERA CORPORATION, CA$304,461ZRG1
2023SPNS2 inhibitors as renal fibrosis therapy1R41DK136371-01A1SANTOS, WEBSTER LS1P THERAPEUTICS INC., VA$301,373ZRG1
2023miRNA-Nanotechnology as a novel regenerative therapy for lymphangioleiomyomatosis1R41HG013603-01A1BRENNER, JACOBKRYMSKAYA, VERA PPLEIMES, DIRKBIOSPUTNIK LLC, NY$301,016ZRG1
2023Genetic adjuvants to elicit neutralizing antibodies against HIV1R43MH133246-01 · under PA-21-262HARTIGAN-O'CONNOR, DENNIS J.SPARGER, ELLEN ELIZABETHTENDEL THERAPIES INC., CA$300,930ZRG1
2023Novel therapeutic intervention of early-stage T1D1R41DK133051-01A1CHEN, XIANTRANSCHROMIX, LLC., NC$300,670ZRG1
2023Developing a new aspiration catheter solution for the treatment of large and medium vessel occlusions1R41NS132732-01BECKER, TIMANEUVAS TECHNOLOGIES, INC., AZ$300,527ZRG1
2023Substance Use Disorder Artificially Intelligent chatbot for screening, assessment & referral: SUD Bot1R41DA059275-01BULL, SHEANA SCLINIC CHAT LLC, CO$300,526ZRG1
2023Next-generation nanomedicine for acute ischemic stroke1R41NS130812-01 · under PA-21-262BRENNER, JACOBNANOMUSE, LLC, NJ$300,454ZRG1
2023An immunotherapeutic IgY formulation against norovirus diarrhea1R41AI172485-01A1GOEPP, JULIUS GSCALED MICROBIOMICS, LLC, MD$300,000ZRG1
2023Therapeutic Agents Targeting Cryptococcal Infections1R41AI172564-01A1WRIGHT, DENNIS L.QUERCUS MOLECULAR DESIGN, LLC, CT$300,000ZRG1
2023Hepatoselective Dihydroquinolizinone (HS-DHQ) Molecules for Treatment and Prevention of Hepatitis A Virus (HAV) Infection1R41AI177204-01DU, YANMINGHARLINGENE LIFE SCIENCES LLC, PA$300,000ZRG1
2023Leptospirosis Vaccine Development1R41AI174377-01A1DEVILLERS, CARLALUNA BIOSCIENCE, INC., CT$300,000ZRG1
2023Precision Glycoengineering of an HCV Envelope-Based Nanoparticle Vaccine1R41AI179330-01HORRIGAN, STEPHEN KEVINNEUIMMUNE BIOLOGICS, INC., MD$300,000ZRG1
2023A novel therapeutic for the treatment of biofilms in periprosthetic joint infections1R41AI179543-01GILBERTIE, JESSICAQENTOROS, LLC, VA$300,000ZRG1
2023Development of small molecule Protease-activated-receptor-2 antagonists as oral asthma therapeutics1R41HL169048-01A1BOITANO, SCOTTDEFEA, KATHRYN ANNEPARMEDICS, INC., CA$300,000ZRG1
2023Development of a first-in-class antiviral to address CMV drug resistance in immunocompromised patients1R42AI174554-01A1RODICK, ROBERTWEINBERGER, LEOR SVXBIOSCIENCES, INC., CA$300,000ZRG1
2023Factor H Fc fusions as novel therapeutics for Burkholderia pseudomallei infections1R41AI177227-01A1WYCOFF, KEITHPLANET BIOTECHNOLOGY, INC., CA$300,000ZRG1
2023Recombinant E-NTPDase for shock1R41GM151882-01HASKO, GEORGEPURINE PHARMACEUTICALS, INC., NJ$299,999ZRG1
2023Novel Combination Therapy for Treatment and Prevention of PulmonaryLymphangioleiomyomatosis (LAM) and Tuberous Sclerosis Complex (TSC)1R41HL164196-01A1KRYMSKAYA, VERA PPLEIMES, DIRKBIOSPUTNIK LLC, NY$299,997ZRG1
2023Targeting macrophage maladaptation for bacterial sepsis treatment1R41AI174362-01A1ZHU, XUEWEIACEPRE, LLC, SC$299,982ZRG1
2023Novel Therapeutics for Heart Failure: Modified, Water-Soluble Caveolin-1 Scaffolding Domain Peptides with Improved Characteristics for Drug Development1R41HL167327-01 · under PA-21-262HOFFMAN, STANLEY RFIBROTHERAPEUTICS, INC., SC$299,972ZRG1
2023Optimizing the synthesis of[18F]FTMP for commercial distribution1R41EB034141-01 · under PA-21-262SELLMYER, MARK AVELLUM BIOSCIENCES LLC, PA$299,927ZRG1
2023Phosphatidylserine-blocking nanoparticles as improved anti-thrombotic with reduced bleeding risk1R41HL167303-01 · under PA-21-262GRAY, BRIAN DAVIDMOLECULAR TARGETING TECHNOLOGIES, INC., PA$299,890ZRG1
2023Dialysate regeneration system based on photo-electrochemical urea oxidation and reactive adsorption to enable portable hemodialysis1R41DK137677-01FULKERSON, BARRYKULEANA TECHNOLOGY, INC., WA$299,646ZRG1
2023Development of a novel sensor for the real-time measurement of mitral coaptation force1R41HL167401-01 · under PA-21-262GRINBERG, DANIELMEDIGO, ANTHONYRAPOPORT, BENJAMIN ISAACMITRALPRINT INC., MI$299,577ZRG1
2023Developing RNA therapeutics for rare neurodevelopmental disorders1R42HD111138-01A1LOTTI, FRANCESCODAYI THERAPEUTICS, INC., TX$299,546ZRG1
2023Innovative medical device to treat nonunion fracture for older adults1R41AG080953-01A1CHEN, MOGUAN, JIANJUNSHEN, JIEWNT SCIENTIFIC, LLC, NY$299,428ZRG1
2023Development of a novel broad spectrum antifungal therapeutic targeting Glycosylphosphatidylinositol (GPI) biosynthesis and cell wall biogenesis1R42AI179344-01ROEMER, TERRYPROKARYOTICS, INC., NJ$299,326ZRG1
2023Preclinical Development of a Novel Therapeutic Agent for Idiopathic Pulmonary Fibrosis1R41HL167504-01A1BOGATKEVICH, GALINA SSILVER, RICHARD M.FIBROBIOLOGICS, LLC, SC$299,295ZRG1
2023Structurally engineered furan fatty acids for the treatment of dyslipidemia and cardiovascular disease1R41HL167544-01A1 · under PA-21-262SCHOPFER, FRANCISCO JOSEFURANICA, INC., PA$299,169ZRG1
2023A novel, non-antibiotic, microbiome-directed agent to prevent post-surgical infection1R42AI174369-01 · under PA-21-262ALVERDY, JOHN CCOVIRA SURGICAL, IL$299,066ZRG1
2023Amadorins as a Novel Oral Therapeutic for Diabetic Retinopathy1R41EY034725-01 · under PA-21-262KHALIFAH, RAJA GPRAETEGO, INC., NC$298,940ZRG1
2023Precision MRI with a Novel Protein Contrast Agent for Early Detection and Staging of Lung Fibrosis1R41HL170898-01YANG, JENNY J.INLIGHTA BIOSCIENCES, LLC, GA$298,840ZRG1
2023Targeting Myosin to Treat Polycystic Kidney Disease1R41DK136452-01FU, HONGXIAPLUREXA LLC, WA$298,326ZRG1
2023Gelbrane: Combined Gel and Membrane for Robust Western Blotting1R41GM151910-01BIRTWISTLE, MARC R.BLOTTING INNOVATIONS, LLC, SC$297,664ZRG1
2023An R2 non-neuroinvasive herpes simplex virus type 2 vaccine1R42AI177202-01SMITH, GREGORY ALLANTHYREOS, INC, IL$297,493ZRG1
2023Development of the HC2099 series of MmpL3 inhibitors to treat tuberculosis1R41AI167105-01A1VRBANAC, JOHN JAMESTARN BIOSCIENCES, INC., MI$297,136ZRG1
2023Evaluating the efficacy of Butyric acid pro-drug nanoparticle in retinal neuroprotection1R41EY034735-01 · under PA-21-262BISWAL, MANAS RNUTRIFORWARD, LLC, TX$296,790ZRG1
2023Vitiligo topical treatment applying a potent, highly selective MC1R agonist1R41AR083311-01ABDEL-MALEK, ZALFAMC1R VENTURES LLC, OH$295,913ZRG1
2023Practice Wellness: Equipping home visitors with skills in reflective coaching, parent mediated child development, and occupational wellness to strengthen child outcomes among low-resourced families1R41HD114332-01JOHNSON-SHELTON, DEBORAHSAAVSUS, INC., OR$295,787ZRG1
2023Development of a Urine Test for At-Home Monitoring of Blood Phe Levels for PKU1R41HD112228-01A1CHAMPAIGNE, KEVIN DCIRCA BIOSCIENCE, LLC, SC$295,724ZRG1
2023Membrane repair as a therapeutic intervention for treating Becker Muscular Dystrophy1R42AR083329-01WEISLEDER, NOAHMYOFINITY BIOSCIENCES INC, MA$295,536ZRG1
2023Feasibility of app-delivered circadian synchronization therapy with light in a cohort of pregnant women1R41HD114317-01WALCH, OLIVIAARCASCOPE, INC, VA$295,128ZRG1
2023Prevention and mitigation of acute traumatic coagulopathy and bleeding1R41HL169120-01MOSNIER, LAURENT OHEMATHERIX, LLC, CA$295,000ZRG1
2023A Machine Learning Algorithm to Assess Functional "Brain Age" from an In-Home EEG Sleepband1R41AG085773-01COMERFORD, MICHAELNEUROGENECES, INC., NM$295,000ZRG1
2023Clusterin Targeting of Ocular Surface Disease1R41EY034396-01A1FINI, M ELIZABETHMASLI, SHARMILAPROTERIS BIOTECH, INC., CA$294,662ZRG1
2023Novel Adipose Targeted Gene Therapy for Lipodystrophy1R41DK138551-01CAO, LEIHAWKINS, ALZVELT THERAPEUTICS INC., OH$293,842ZRG1
2023Structurally engineered N-acyl amino acids for the treatment of NASH1R41DK137711-01SCHOPFER, FRANCISCO JOSEFURANICA, INC., PA$293,543ZRG1
2023Systemic Transplantation of MyoPAXon: IND Enabling Studies for the Treatment of DMD1R42AR083779-01KYBA, MICHAELPERLINGEIRO, RITA C. R.MYOGENICA INC., MN$292,719ZRG1
2023Advanced optics to unlock large field-of-view multiphoton imaging for neuroscience and beyond1R41MH136563-01SMITH, SPENCER LAVEREPACIFIC OPTICA, INC., CA$292,576ZRG1
2023Genome Editing Therapy for Usher Syndrome Type 31R42EY035582-01IANNUZZI, MICHAEL CYANG, DONGSHANGENETOBE INC., MI$289,895ZRG1
2023IgE-suppressing small molecule compound Xanthopurpurin analog for multiple food allergies1R41AI172572-01A1LI, XIU-MINYANG, NANGENERAL NUTRACEUTICAL TECHNOLOGY, LLC, NY$289,622ZRG1
2023Time-resolved laser speckle contrast imaging of resting-state functional connectivity in neonatal brain1R42MH135825-01YU, GUOQIANGBIOPTICSTECHNOLOGY, LLC, KY$289,075ZRG1
2023Preclinical evaluation of SERCA2 allosteric activators for pancreatic β-cell protection in diabetes.1R41DK134247-01A1DAHL, RUSSELLNEURODON LLC, IN$286,348ZRG1
2023Demonstrating miniaturized production of a KOR PET tracer as a proof-of-concept for low-cost distribution of nascent PET neurotracers1R41DA059980-01JONES, JASONDROPLETPHARM INC., CA$286,331ZRG1
2023Development of Nicotinamide-Riboside plus Pterostilbene as a Disease Modifying Osteoarthritis Therapeutic1R41AR082748-01BRYAN, RUDELLINGER, RYAN WILLIAMELYSIUM HEALTH, INC., NY$283,071ZRG1
2023Addressing bone marrow lesions that compromise osteochondral tissue repair1R41AR083778-01WILLARD, VINCENT PCYTEX THERAPEUTICS INC., NC$282,265ZRG1
2023Advanced Quantitative Magnetic Resonance Imaging Phantoms for Nonalcoholic Fatty Liver Disease1R41EB033717-01A1BRITTAIN, JEAN H.REEDER, SCOTT B.CALIMETRIX, LLC, WI$282,252ZRG1
2023Development of Antisense Oligonucleotides to Regulate Gamma' Fibrinogen Levels1R41HL170874-01FARRELL, DAVID HENRYGAMMA THERAPEUTICS, INC., OR$277,710ZRG1
2023Wearable Array for Ultrasound Stimulation on the Retina1R41EY035609-01CHABOK, HAMID REZAZHOU, QIFAPHONONZ INC, CA$276,306ZRG1
2023Production of radiometal-based radiopharmaceuticals at a clinical scale via droplet-scale radiochemistry1R41EB034168-01A1JONES, JASONDROPLETPHARM INC., CA$275,773ZRG1
2023Recognition of O-GlcNAc Modified Proteins Using Site-Specific Antibodies1R43HL166086-01A1POPOV, MARLAGLYCOSCIENTIFIC, LLC, GA$275,767ZRG1
2023Audiom: Developing an Indoor Non-Visual Mapping System1R41EY034411-01A1BIGGS, BRANDONXR NAVIGATION INC., CA$275,766ZRG1
2023Deep-UV Microscopy for Real-Time Adequacy Analysis of Bone Marrow Aspirates1R41EB035057-01ROBLES, FRANCISCO ECELLIA SCIENCE, INC., AR$275,766ZRG1
2023Novel probiotics to mitigate xenobiotic toxicity through microbial biotransformation1R41ES034979-01A1MOFRAD, MOHAMMAD RKSHIRAZI, FATEMEHSOHEILYPOUR, MOHAMMADNEXILICO, INC., CA$275,765ZRG1
2023Feasibility and design of a novel smartphone app to deliver blood pressure-lowering inspiratory muscle strength training1R41HL167375-01A1SEALS, DOUGLAS RKLEIN BUENDEL, INC., CO$275,764ZRG1
2023Ultrasound-coupled Electrical Impedance Tomography for Sarcopenia Assessment1R41AG082635-01A1HALTER, RYAN JOSEPHRYTEK MEDICAL, INC., NH$275,762ZRG1
2023Protection of transplanted heart function by regulation of Na/K pump activity1R41HL165958-01A1CHEN, WEILIU, RUISHENGWR BIOTECH, LLC, FL$275,739ZRG1
2023Translational development of novel CRISPR approach to treat genomic duplications1R41AR082205-01A1LEK, MONKOLMYOFINITY BIOSCIENCES INC, MA$275,651ZRG1
2023Biomarkers for Brain Resetting as an Assistive Tool in the Treatment of Status Epilepticus1R41NS132627-01JASSEMIDIS, LEONIDAS DEPIFOCUS LLC, AZ$275,572ZRG1
2023Physics-informed Machine Learning approach for a selective, sensitive, and rapid sensor for detecting unsafe levels of carcinogenic/toxic VOCs1R41ES034936-01 · under PA-21-262ATTARIANI, HAMEDPROMETHEUS TECHNOLOGIES, LLC, OH$275,554ZRG1
2023Glycan biomarker panels in liquid biopsies for predicting treatment response in lupus nephritis1R41DK135167-01 · under PA-21-262CASTELLINO, STEPHENNOWLING, TAMMY (TAMARA)GLYCOPATH, INC, SC$275,397ZRG1
2023Enhanced CRISPR gene editing in pluripotent stem cells using carbon nanotube arrays1R41GM150320-01DICKERSON, IAN MSCHRLAU, MICHAEL GEORGEADVANCED GENE TRANSFER COMPANY, INC., NY$275,045ZRG1
2023Structure-based computational engineering of saCas9 PAM requirement1R41GM149016-01A1HUANG, XIAOQIANGXIA, XIAOFENGATGC, INC., MI$274,955ZRG1

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