Centrifugation for Researchers

Centrifugation is a useful way to separate particles using a centrifuge, and it is a method that has many applications in the life sciences, particularly in molecular biology. There are different types of centrifuges that can be used for various applications, including research into organelles and biological molecules. Theory of Centrifugation The theory behind centrifugation […]

Quinolinic acid rat HD model

Introduction Huntington’s disease (HD) is an inherited autosomal dominant neuropathological disease caused by a mutation in the huntingtin gene (htt). Preclinical animal models are necessary for the study of HD and the development of therapeutic interventions for the disease. Ideally, an animal model should demonstrate all the behavioral and neuropathological characteristics observed in HD patients. […]

Implementation Science: Improving Evidence-Based Practice and Healthcare Quality

Implementation Science: The Key to Optimizing Health Outcomes around the Globe What does it take to increase patient satisfaction and health outcomes across the globe? How can research address real-life settings and target users of research, not only the pure production of knowledge? Is controlling for research variables in laboratory settings and recruiting participants who […]

Measuring Research Success: H-index Scores in Science

What Are H-index Scores? H-index scores are popular metrics used to assess scientific performance. They can indicate both the quantity and quality of a scientist’s work, based on the number of publications they have published and their citation rates. The larger the number of cited papers a researcher has, the higher the h-index they get. […]

3-Nitropreopionic acid Huntington’s disease model

Introduction 3-Nitropropionic acid (3-NP) is a selective striatal neurotoxin used in rodents to mimic pathological features of Huntington’s disease. 3-Nitropropionic acid interrupts the mitochondrial electron transport chain. This mycotoxin is an inhibitor of succinate dehydrogenase, an enzyme responsible for the oxidation of succinate to fumarate. This process reduces ATP production and causes oxidative stress. Generally, […]

Radiation: Friend or Foe? What Can We Learn From Radiobiology?

We are routinely exposed to radiation. Simply, radiation is the propagation of energy in the form of waves or particles through material in space (Mu et al., 2018). The world is full of background radiation to which we are constantly exposed. Everything we see and hear comes to us in the form of radiation. Radiation […]

Colorimetry- a comprehensive guide for your color science

  Overview of Colorimetry Colorimetry, as the name suggests, means the measurement of colors. In terms of chemical analysis, it is, more specifically, the measurement of the concentration of a particular compound (solute) in a colored solution (solvent). During scientific work, we often need to measure quantities of a particular compound in a mixture or […]

The Basics of Infrared Spectrophotometry

Spectroscopy refers to the interaction between electromagnetic (EM) radiation and matter as a function of its frequency or wavelength.  From this, a number of quantitative and qualitative measurements defining aspects like sample concentrations, structure, chemical compositions etc, can be obtained depending on the spectroscopic technique and spectrum of EM radiation used.  When EM radiation interacts […]

Mastering the Microtome

Need Microtomes for your studies? Click here Description of Microtome Generally, microtomes are involved in the process of preparing samples of biological material to be examined under a microscope. Specifically, they slice material into extremely thin pieces so they can fit in a microscope slide and be studied by researchers. It holds the material in […]