Description
Mouse Features |
Sound attenuating chamber |
Mouse Enclosure |
Tremor Sensor |
Conduct software |
Rat Features |
Sound attenuating chamber |
Mouse Enclosure |
Tremor Sensor |
Conduct software |

Take advantage of Neuralynx, Ethovision Integration, SMS and Email integration with the Conductor Science Software. No I/O Boxes Required
Features
- 55cm x 42cm x 55cm (width x depth x height) (dimensions are customizable, please request)
- Multi-layer sound-proof insulation material that attenuates environmental disturbance
- LED house light (manual)
- Automated IR light
- Automated air circulation fan
- Camera mount
- Pull-out floor shelf (optional)
- Acrylic cage with lid
- Dimensions: mouse 17 x 17 x 25cm (width x depth x height) cm and rat 26 x 26 x 30 cm (width x depth x height)
- Front circular door – The door open in the middle
- Feces and urine tray – removable for feces and urine removal
- Support up to eight Tremor Monitor stations: Each station has one control box that controls its operations
- The main control box connects to up to 16 chamber control boxes via wireless communication. The wireless
eliminates many cable connections between the main control box and all (up to 8) stations - The main controller connects to the PC via a USB (RS-232) cable and communicates with Maze Engineers
Conduct Tremor software on the PC
- No TTL is required
- Export real-time recorded data from the control box to PC
- The Conduct Tremor software is used to configure and run experiments. The software is intuitive and precise
with easy installation - The user can specify frequencies (for example at 128Hz) to be monitored
- The data are presented and charted for analysis via FFT that shows the most powerful frequency recorded
- The ability to run up to 60 minutes and the data can be reviewed in adjustable intervals such as 1-minute or 2-
minutes - Support up to 8 stations simultaneously
- Ultra-sensitive piezoelectric disk
- Record continuous movement waveforms at 1 to 128 (Hz) in real-time for up to 60 minutes

Apparatus and Equipment
The design of the Rodent Tremor Chamber integrates a sound-attenuating enclosure, rodent support apparatus, tremor detection sensor, and software suite for recording, analyzing, and exporting data.
Rodents modeled for tremors and control strains are securely positioned within the holder to facilitate precise tremor analysis.
For accurate rodent positioning, advanced video tracking software solutions like Noldus EthoVision, ANY-Maze, or BehaviorCloud can be utilized to monitor rodent movements within the chamber.
Training Protocol
Set up protocol parameters using the Conduct software package, including experimental timing and other variables.
Introduce subjects into the rodent enclosure and provide a 10-minute habituation period.
Initiate tremor measurement using the Conduct software.
Record tremor frequencies and event counts, exporting the data to a PC for further analysis.
Data Analysis
The following parameters can be measured using te rodent temor chamber:
- Number of tremors in a given time
- Type of tremor
- The severity of the tremor
- Response of the tremor to treatment.
Literature Review
Summary
The Rodent Tremor Chamber allows for ultra-sensitive measurements of tremor in rat and mouse models.
- The apparatus is composed of a sound-attenuating chamber, rodent enclosure, tremor sensor, control box, and Conduct software.
- Continuous movement waveforms can be recorded at 1-128 Hz in real-time for up to 60 minutes.
References
Gardner, D. R., Welch, K. D., Lee, S. T., Cook, D., & Riet-Correa, F. (2018). Tremorgenic Indole Diterpenes from Ipomoea asarifolia and Ipomoea muelleri and the Identification of 6,7-Dehydro-11-hydroxy-12,13-epoxyterpendole A. Journal of Natural Products, 81(7), 1682–1686. doi:10.1021/acs.jnatprod.8b00257
Paterson, N. E., Malekiani, S. A., Foreman, M. M., Olivier, B., & Hanania, T. (2009). Pharmacological characterization of harmaline-induced tremor activity in mice. European Journal of Pharmacology, 616(1-3), 73–80. doi:10.1016/j.ejphar.2009.05.031