The Horizontal Ladder test is a motor and coordination test for evaluating skilled walking for mice and rats. Steps are counted and classified as either correct/functional paw placement, a slip, or a miss. Fore & hind-limb coordination can be assessed further by removing individual ladder rungs to evaluate how the rodent targets individual rungs.
The animals are required to walk on a horizontal rung ladder spontaneously with varied spacing between rungs. The MazeEngineers horizontal ladder allows for the removal of individual rungs. Flexibly made to clamp to end plates to allow for aversive or rewarded locomotion. Clear walls allow for easy video recording.
Weight Drop TBI models are used to replicating focal cerebral contusions as well as traumatic, diffuse brain injury by axonal damage. Attach a metal loop to the top end of the desired weight allowing the fishing line to be fastened to the weight. The plastic guide tube is held in place with a clamp stand and positioned above the scored tin foil. The fishing line is then attached through the metal loop to the weight ensuring that the bottom of the weight hangs freely over the scored tin foil. The fishing line is then connected to the clamp stand, and the weight is drawn up through the plastic guide tube with the fishing line and secured in its position with an Allen key pin.
Scavenging machines are used in the collection and removal of waste anesthetic gases (WAGs) vented during the anesthetization processes. These systems comprise collection devices, interfaces, and disposal systems. Scavenging machines also help monitor the gases and prevent barotrauma to the subject resulting from a change in incoming and outgoing gas flow.