Range of Forces: Monofilaments are available in different thicknesses and force levels, allowing sensitivity testing from very low to higher pressure levels, making them suitable for various pain conditions.

Reproducibility: The use of these filaments provides reproducible and consistent results in assessing mechanical sensitivity, which is crucial for comparative studies.

Ease of Use: Both the manual and electronic methods are relatively easy to use, making them applicable in research laboratories and clinical settings.

Portability: The monofilaments are lightweight and easy to transport, allowing tests to be conducted in different environments and with various subjects without the need for heavy equipment.

Minimal Interaction: The non-invasive nature of the method allows for sensitivity evaluation without causing additional pain or significant stress to the subject, which is especially important in studies involving animals.

Quantitative Assessment: It allows not only the observation of withdrawal thresholds but also quantifies the degree of mechanical hypersensitivity, facilitating statistical analysis of the data.

Flexibility in Application: The filaments can be used on various body areas, not just the plantar surface, enabling nociception assessment at different sites.

Clinical and Preclinical Studies: Von Frey monofilaments are utilized in a wide range of studies, from basic research to clinical trials, making them a versatile tool in pain assessment.

Temporal Change Analysis: The ability to perform repeated tests on the same subject allows for the evaluation of changes in mechanical sensitivity over time, useful for studying disease progression or treatment responses.