5ch Multi-output Small Animal Anesthesia Machine
The Anesthesia Machine with Multimodal Output is designed to deliver safe and precise anesthesia administration during surgical procedures. This advanced anesthesia machine, available from Conduct Science, combines technology with user-friendly features to ensure optimal patient care and ease of use. The Anesthesia Machine with Multimodal Output offers a comprehensive range of functionalities to meet the diverse needs of anesthesia procedures. It features advanced ventilation modes, precise gas delivery control, and comprehensive monitoring capabilities, allowing for seamless management of anesthesia during surgical procedures.
Louise Corscadden, PhD
Neuroscience · ConductScience
Ask Louise about 5ch Multi-output Small Animal Anesthesia Machine fit, setup, configuration, or quote prep.
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Five-channel manifold cheat sheet
- 0-4 L/min O2 flowmeter, 10 L/min flush, and an independent 0-2 L/min chamber tap per OEM spec.
- Each cone/mask tap is valved so you can run 1-5 animals and keep balanced induction without swapping hoses mid-study.
- BPLabLine advertises R550IE/SE at $3,240; ConductScience mirrors that split ($3,200 Iso / $3,330 Sevo) while bundling US calibration plus spare seals.
Documentation: RWD R550 spec | BPL public MSRP
R550 is a Multi-output Laboratory Small Animal Anesthesia Machine, which is suitable for the simultaneous anesthesia of 1-5 rats, mice, cats, rabbits, and other animals. Each channel for anesthesia can be controlled independently. It will help you save a lot of time during research. The gas flow of the induction box can be adjusted independently, with a range of 0-2.0L/min.
Specifications
| Model | Product Description | Remarks |
|---|---|---|
| RWD-R550IE | Enhanced Small Animal Anesthesia Device-Isoflurane ,Easy Fill, 0-4L | Contains connection tubing for mask & Induction chamber |
| RWD550SE | Enhanced Small Animal Anesthesia Device -Sevoflurane, Easy Fill, 0-4L | Contains connection tubing for mask & Induction chamber |
Evaporation Tank Details
| Evaporation Tank | Specifications |
|---|---|
| Calibration method | Laser calibration technology |
| Output concentration | 0.50%-5.00% (Isoflurane); 0.50%-8.00% (sevoflurane) |
| Output accuracy | ±0.1 (0-1%); ±0.15 (>1%) |
| Anesthetic capacity | 120 ml (volume between the maximum and minimum two tick marks) |
Features
- Multi-channel design can meet the needs of multiple animals(1-5 small animals) simultaneously
- Accurate oxygen flow meter, Flow control range: 0-4L/min available
- High accuracy vaporizer (Each one has an independent test report)
- Gas toggle switch, button switching gas path, more than 100,000 times of service life.
- Quick oxygenation switches to remove residual anesthetic mixture in the tube or anesthesia induction chamber.
- Oxygen or air can be chosen as a gas supply.
- Easy Fill, Key Fill for adding drugs is optional.
- Can be upgraded into a portable anesthesia machine to save space and facilitate movement
- The gas flow of the induction chamber can be adjusted independently, ranging from 0 to 2.0 L/min.
- Toggle switch, quick switching of the gas circuit, 100 thousand times of life
Protocol
- Accommodates animals ranging in size from neonate mice to rabbits.
- Six outputs supply anesthesia to the induction chamber and up to five masks.
- Incorporates two flowmeters: one controls the vaporizer (0-4000cc/min) and the other one controls the induction chamber (0-2500cc/min).
- Allows investigator flexibility in designing protocols without calculations.
- Each output (mask) is individually controlled with a simple ON/OFF toggle switch.
- Push-button oxygen flush purges induction chamber before removing animals.
- Carry handle facilitates safe, easy transport of the unit.
- Available in both tabletop and wall mount, and optional post mount with 5-leg spider base (ask for more information)
- The built-in temperature compensator ensures the stable concentration of anesthetic gas at different temperatures and flow rates, the flow range is 0.2-10L/min;
Additional Features & Information
Our RWD-R550 Multi-output Anesthesia Machine (size 13x6.75x12.8inch) is our most advanced system and offers highly efficient, a precise gas flow that is easy to use.
- Mixed anesthetic gas output pressure range △ P ≤ 2.5kPa;
- Applicable temperature range: 10-35 ℃;
- Good tightness, internal 50kPa pressure can be maintained, zero leakage, safe and reliable;
- Internal capacity is not less than 120ml, and the range of isoflurane vaporizer concentration is 0-5% (Sevoflurane: 0-8%);
- Anti-accident open lock structure and closed state security protection structure to ensure safety
Note: manifold with 4LPM Flowmeter Vaporizers, Inlet/Outlet End Caps, are included in the RWD-R550 series anesthesia machine
Summary
- Multi-output Design: Can anesthetize 1-5 animals (rats, mice, cats, rabbits) simultaneously.
- Independent Control: Each channel has its own control, allowing for efficient and flexible research.
- Accurate Vaporizer: High precision with independent calibration for reliable output.
- Gas Flow: Adjustable flow for both induction chamber and masks (0-4L/min, 0-2L/min for induction).
- Durable: Over 100,000 toggle switch operations, with options for oxygen flush and portable upgrades.
- Safety: Stable anesthetic concentration with temperature compensator and anti-accident features.
Manufacturer Source: https://www.rwdstco.com/product-item/r550-multi-output-anesthesia-machine/
How It Works
The system operates through precision vaporization of volatile anesthetic agents using laser-calibrated concentration control technology. Pressurized oxygen enters the system through calibrated flow meters and passes through agent-specific vaporizers where volatile anesthetic (isoflurane or sevoflurane) undergoes controlled evaporation. The vaporizer chamber maintains agent concentration through temperature compensation and precise vapor pressure regulation, ensuring accurate anesthetic delivery regardless of ambient temperature variations within the 10-35°C operating range.
Each output channel receives the mixed anesthetic-oxygen combination through independent flow paths, allowing differential flow rates while maintaining consistent concentration delivery. The induction chamber connection provides higher flow capacity (0-2.0 L/min) for rapid anesthetic uptake during initial induction phases, while individual mask connections deliver maintenance concentrations through lower flow rates optimized for specific animal weights and metabolic demands.
Gas delivery pressure is regulated to ≤2.5 kPa output pressure, providing gentle positive pressure ventilation support while preventing barotrauma in spontaneously breathing animals. Internal pressure monitoring maintains 50 kPa system pressure with zero leakage tolerance, ensuring consistent agent delivery and preventing atmospheric contamination during extended procedures.
Features & Benefits
Anesthetic Agent
- Isoflurane
- Sevoflurane
number_of_outputs
- 6 outputs (1 induction chamber + 5 masks)
simultaneous_animals
- 1-5 animals
vaporizer_flow_range
- 0-4000cc/min (0-4L/min)
induction_chamber_flow_range
- 0-2500cc/min (0-2L/min)
mixed_anesthetic_gas_output_pressure
- ≤2.5kPa
internal_capacity
- ≥120ml
isoflurane_concentration_range
- 0-5%
sevoflurane_concentration_range
- 0-8%
vaporizer_flow_range_with_compensator
- 0.2-10L/min
internal_pressure_maintenance
- 50kPa with zero leakage
toggle_switch_life
- 100,000 operations
animal_size_range
- neonate mice to rabbits
mounting_options
- tabletop, wall mount, optional post mount with 5-leg spider base
Anesthetic Agent
- Isoflurane
- Sevoflurane
Vaporizer Type
- Easy Fill
Automation Level
- semi-automated
Temperature Range
- 10-35°C
Species
- Rabbit
- Mouse
- Rat
Dimensions
- 13 inch x 6.75 inch x 12.8 inch
Brand
- RWD
Research Domain
- Addiction Research
- Aging Research
- Behavioral Pharmacology
- Cancer Research
- Cardiovascular Research
- Metabolic Research
- Neuroscience
- Pain Research
- Toxicology
Weight
- 22.05 kg
Dimensions
- L: 34.0 mm
- W: 39.0 mm
- H: 33.0 mm
| Feature | This Product | Typical Alternative | Advantage |
|---|---|---|---|
| Number of simultaneous animals | 1-5 animals with independent flow control per channel | Single-channel systems require sequential procedures | Enables parallel experimental procedures, reducing protocol duration and improving experimental consistency across subjects. |
| Concentration accuracy | ±0.1% (0-1%) and ±0.15% (>1%) with laser calibration | Basic systems often provide ±0.5-1.0% accuracy | Precise concentration control enables reproducible anesthetic depth management critical for physiological research applications. |
| Vaporizer capacity | 120ml between min/max markings | Entry-level systems typically offer 50-100ml capacity | Extended operational duration reduces experimental interruption and supports multi-day research protocols without frequent refilling. |
| Flow rate range | 0-4 L/min main flow, 0-2 L/min induction chamber | Basic systems often limited to 0-2 L/min total flow | Broader flow range accommodates different species weights and supports both rapid induction and maintenance phase requirements. |
| Output pressure regulation | ≤2.5 kPa mixed gas output pressure | Standard systems vary from 1-5 kPa output pressure | Gentle positive pressure delivery prevents barotrauma while maintaining adequate ventilation support for spontaneously breathing animals. |
| Agent compatibility | Dedicated models for isoflurane (R550IE) or sevoflurane (R550SE) | Universal vaporizers may compromise agent-specific optimization | Agent-specific calibration ensures optimal performance characteristics for chosen anesthetic protocol requirements. |
The R550 series provides multi-channel anesthetic delivery with research-grade precision control, combining the throughput advantages of parallel processing with the accuracy specifications required for physiological research applications. The laser-calibrated vaporizer technology and independent channel control deliver superior performance compared to entry-level single-channel systems while maintaining compact laboratory footprint.
Practical Tips
Verify vaporizer output concentration monthly using a calibrated anesthetic agent analyzer, particularly before initiating new research protocols.
Why: Laser calibration technology maintains accuracy over time, but periodic verification ensures continued research-grade precision for critical experiments.
Replace vaporizer seals and gaskets according to manufacturer schedule or when agent consumption increases unexpectedly.
Why: Seal integrity directly affects concentration accuracy and prevents atmospheric contamination in laboratory environments.
Calculate species-specific flow rates based on 2-3x metabolic oxygen consumption to ensure adequate anesthetic delivery without excessive dead space ventilation.
Why: Proper flow rate selection maintains physiological stability while optimizing anesthetic agent utilization and minimizing waste.
Install scavenging systems on all output connections to prevent atmospheric accumulation of anesthetic vapors during extended research sessions.
Why: Volatile anesthetics require proper ventilation management to maintain safe laboratory working conditions and regulatory compliance.
Monitor individual channel flow rates during multi-animal procedures to detect potential blockages or connection issues before they affect experimental outcomes.
Why: Independent flow monitoring enables immediate intervention if individual channels experience reduced delivery, preventing anesthetic depth variation across subjects.
Record baseline vaporizer settings and individual flow rates for each research session to ensure protocol reproducibility across experimental timepoints.
Why: Systematic documentation enables precise protocol replication and supports regulatory documentation requirements for research compliance.
Allow 10-15 minutes warm-up time after agent filling or system startup to ensure vaporizer temperature equilibration and stable concentration delivery.
Why: Temperature compensation requires thermal equilibrium for optimal accuracy, particularly important when transitioning between different laboratory ambient conditions.
Use separate induction chamber flow settings (0-2 L/min range) for initial anesthesia followed by reduced maintenance flows through individual mask connections.
Why: Higher induction flows accelerate anesthetic uptake while lower maintenance flows provide economic agent utilization and stable long-term anesthesia.
Setup Guide
What’s in the Box
- 5-channel anesthesia machine main unit
- Agent-specific vaporizer (isoflurane R550IE or sevoflurane R550SE)
- Induction chamber connection tubing
- 5 individual mask connection tubes
- Oxygen inlet connection hardware
- Operation manual and calibration certificate
- Mounting hardware for tabletop installation
- Gas outlet port caps (typical)
- Flow meter calibration documentation (typical)
Warranty
ConductScience provides a comprehensive 1-year manufacturer warranty covering system components and vaporizer calibration accuracy, with technical support for protocol optimization and troubleshooting throughout the warranty period.
Compliance
References
Background reading relevant to this product:
What is the concentration accuracy across the full operational range for both isoflurane and sevoflurane?
The system provides ±0.1% accuracy for concentrations 0-1% and ±0.15% accuracy for concentrations >1%. Isoflurane systems operate from 0.5-5.0% while sevoflurane systems span 0.5-8.0% concentration ranges, with laser calibration technology maintaining accuracy specifications throughout the operational range.
Can each channel operate at different flow rates and concentrations simultaneously?
Yes, each of the 5 mask channels receives the same vaporizer-controlled anesthetic concentration but individual flow rates can be adjusted independently through separate flow control mechanisms. The induction chamber operates with independent flow control from 0-2.0 L/min while mask channels utilize the main flow range of 0-4 L/min.
What animal weight ranges are appropriate for this system?
The system accommodates neonate mice through rabbits, with flow control capabilities suitable for animals from approximately 20g (adult mouse) up to 3-4 kg (adult rabbit). Species-specific flow rates should be calculated based on metabolic oxygen requirements and anesthetic uptake characteristics.
How frequently does the vaporizer require calibration verification?
Vaporizer accuracy should be verified quarterly or before critical research protocols using calibrated gas analysis equipment. The 120ml capacity and ±0.15% accuracy specifications maintain stability during extended use, but periodic verification ensures continued research-grade performance.
What is the maximum ambient temperature for reliable operation?
The system operates reliably within 10-35°C ambient temperature range. Temperature compensation within the vaporizer maintains concentration accuracy throughout this range, but laboratory temperature control improves long-term stability and calibration maintenance.
Can the system operate with both N2O/O2 mixtures and pure oxygen?
Product specifications indicate oxygen flow control from 0-4 L/min, designed for medical-grade oxygen input. For N2O/O2 mixture compatibility or alternative carrier gas applications, consult product datasheet for specific gas mixture specifications and flow compensation requirements.
What mounting options are available for different laboratory configurations?
The system includes tabletop mounting hardware standard, with optional wall-mount brackets and post-mount configurations with 5-leg spider base available. The compact 13 x 6.75 x 12.8 inch footprint accommodates most laboratory bench configurations while maintaining access to all controls and connections.
How does this system compare to single-channel anesthesia machines for research applications?
Multi-channel capability enables simultaneous procedures on 1-5 animals with independent flow control, significantly increasing research throughput compared to sequential single-animal anesthesia. The shared vaporizer design maintains concentration consistency across channels while reducing equipment cost compared to multiple single-channel units.
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