Research data · Disease model
Multiple sclerosis and demyelination
From 2021 to 2025, 223 animal research papers on multiple sclerosis and demyelination mentioned at least one behavioral test, most often the rotarod.
That is 3.4 times the 66 papers of 2011 to 2015. Papers that mention any of the 90 tests grew to 1.2 times as many over the same span.
The tests these papers mention
The rotarod appears in 30% of the papers on multiple sclerosis and demyelination and in 5.7% of all 32,277 papers that mention a test. That makes it 5.2 times as common in this research. Each bar counts the papers from 2021 to 2025 on multiple sclerosis and demyelination that mention the test, with its share of the 223 papers. A paper that mentions two tests counts under both.
The 15 tests these papers mention most
All 41 tests these papers mention
| Test | Papers | Share of the 223 papers on multiple sclerosis and demyelination | Share of all 32,277 papers that mention a test |
|---|---|---|---|
| Rotarod | 66 | 30% | 6% |
| Morris water maze | 34 | 15% | 17% |
| Open field | 27 | 12% | 12% |
| Y-maze | 24 | 11% | 6% |
| Grip strength | 22 | 10% | 4% |
| Beam walking | 17 | 8% | 2% |
| Novel object recognition | 16 | 7% | 9% |
| Treadmill running | 15 | 7% | 6% |
| Elevated plus maze | 15 | 7% | 9% |
| Wire hang and inverted grid | 14 | 6% | 1% |
| Von Frey test | 12 | 5% | 4% |
| Tail suspension test | 11 | 5% | 4% |
| Gait analysis | 11 | 5% | 3% |
| Forced swim test | 8 | 4% | 9% |
| Passive avoidance | 7 | 3% | 4% |
| Wheel running | 6 | 3% | 3% |
| Fear conditioning | 5 | 2% | 6% |
| Sucrose preference test | 5 | 2% | 5% |
| Hot plate | 5 | 2% | 2% |
| Pole test | 4 | 2% | under 1% |
| Prepulse inhibition and acoustic startle | 4 | 2% | 2% |
| Nest building | 3 | 1% | 1% |
| Grid walking (foot fault) | 3 | 1% | under 1% |
| Radial arm maze | 2 | 1% | 1% |
| Barnes maze | 2 | 1% | 2% |
| Ladder rung walking | 2 | 1% | under 1% |
| Negative geotaxis and climbing assays | 2 | 1% | 1% |
| Tail flick | 2 | 1% | 2% |
| Paw pressure test | 2 | 1% | under 1% |
| Touchscreen operant tasks | 1 | under 1% | under 1% |
| Operant conditioning | 1 | under 1% | 3% |
| Three-chamber sociability test | 1 | under 1% | 1% |
| Predator odor exposure | 1 | under 1% | 1% |
| Resident-intruder test | 1 | under 1% | under 1% |
| Self-grooming | 1 | under 1% | 1% |
| Elevated zero maze | 1 | under 1% | under 1% |
| Active place avoidance | 1 | under 1% | under 1% |
| Hargreaves plantar test | 1 | under 1% | 1% |
| Formalin test | 1 | under 1% | 2% |
| Attentional set shifting | 1 | under 1% | under 1% |
| Olfactory tests | 1 | under 1% | under 1% |
Papers by year
Animal research papers on multiple sclerosis and demyelination that mention a behavioral test, by year, 2001 to 2026
The 2026 bar counts papers added to PubMed by November 8, 2026.
- Papers in a full year
- 2026 so far
Show the counts for each year
| Year | Papers |
|---|---|
| 2001 | 0 |
| 2002 | 2 |
| 2003 | 4 |
| 2004 | 5 |
| 2005 | 5 |
| 2006 | 6 |
| 2007 | 4 |
| 2008 | 5 |
| 2009 | 13 |
| 2010 | 5 |
| 2011 | 6 |
| 2012 | 9 |
| 2013 | 19 |
| 2014 | 12 |
| 2015 | 20 |
| 2016 | 20 |
| 2017 | 19 |
| 2018 | 32 |
| 2019 | 37 |
| 2020 | 34 |
| 2021 | 44 |
| 2022 | 49 |
| 2023 | 41 |
| 2024 | 43 |
| 2025 | 46 |
| 2026 (part year) | 45 |
Which species the papers used
Each bar is a share of the 223 papers from 2021 to 2025. A paper can use more than one species, so the shares can add to more than 100%.
Species
“Other animals” counts papers that use none of the other species in this chart.
Which papers count
A paper counts here when it is animal research, mentions at least one of the 90 tests and studies multiple sclerosis and demyelination.
A paper counts under multiple sclerosis and demyelination when its MeSH terms, the subject headings PubMed adds when it indexes a paper, include one of these.
- Multiple Sclerosis, with the headings under it
- Encephalomyelitis, Autoimmune, Experimental
- Demyelinating Diseases
For a paper PubMed has not indexed, PubTator 3, NCBI's text-mining service, supplies the disease model when it finds the disease in the title or abstract. A paper can count under more than one disease model.
Each paper and its disease models are in the downloads. The full method, with each source and its terms of use, is on our main page, Behavioral tests in published research.
More disease models
These disease models also have a page, with their papers from 2021 to 2025 that mention a test. Each disease model with 100 or more such papers gets one.
- Cognitive impairment and dementia 4,961
- Anxiety 3,041
- Depression 2,827
- Pain conditions 2,617
- Alzheimer disease 2,445
- Substance use disorders 1,599
- Psychological stress 1,484
- Stroke and brain ischemia 1,278
- Parkinson disease 918
- Brain injury 841
- Diabetes 795
- Obesity and high-fat diet 761
- Aging 700
- Epilepsy and seizures 572
- Autism spectrum disorder 484
- Schizophrenia and psychosis 401
- Sleep loss and sleep disorders 400
- Post-traumatic stress 392
- Spinal cord injury 382
- Amyotrophic lateral sclerosis 108
- Attention deficit hyperactivity disorder 107
How to cite
APA
ConductScience. (2026, November 10). Behavioral tests in multiple sclerosis and demyelination research [Data set]. https://conductscience.com/data/behavioral-tests/models/multiple-sclerosis
BibTeX
@misc{conductscience_multiple_sclerosis_2026,
author = {{ConductScience}},
title = {Behavioral tests in multiple sclerosis and demyelination research},
year = {2026},
month = nov,
url = {https://conductscience.com/data/behavioral-tests/models/multiple-sclerosis},
note = {Data set, released November 10, 2026},
}Shop apparatus by test
Our store sells apparatus for nine of the 10 tests these papers mention most, all but wire hang and inverted grid.
- Rotarod
- Morris water maze
- Open field
- Y-maze
- Grip strength
- Beam walking
- Novel object recognition
- Treadmill running
- Elevated plus maze
