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Protocols
November 8, 2019

Quinolinic acid rat HD model

Huntington’s disease (HD) is an inherited autosomal dominant neuropathological disease caused by a mutation in the huntingtin gene (htt). Preclinical animal models are necessary for the study of HD and the development of therapeutic interventions for the disease. Ideally, an animal model should demonstrate all the behavioral and neuropathological characteristics…
Science
November 7, 2019

Measuring Research Success: H-index Scores in Science

H-index scores are popular metrics used to assess scientific performance. They can indicate both the quantity and quality of a scientist’s work, based on the number of publications they have published and their citation rates. The larger the number of cited papers a researcher has, the higher the h-index they…
Protocols
November 7, 2019

3-Nitropreopionic acid Huntington’s disease model

3-Nitropropionic acid (3-NP) is a selective striatal neurotoxin used in rodents to mimic pathological features of Huntington’s disease. 3-Nitropropionic acid interrupts with the mitochondrial electron transport chain. This mycotoxin is an inhibitor of succinate dehydrogenase, an enzyme responsible for the oxidation of succinate to fumarate. This process reduces ATP production…
colorimetry
Lab Basics
October 27, 2019

Colorimetry- a comprehensive guide for your color science

Overview of Colorimetry Colorimetry, as the name suggests, means measurement of colors. In terms of chemical analysis, it is, more specifically, the measurement of the concentration of a particular compound (solute) in a colored solution (solvent). During scientific work, we often need to measure quantities of a particular compound in…
basics of infrared spectrophotometry
Lab Basics
October 10, 2019

The Basics of Infrared Spectrophotometry

Spectroscopy refers to the interaction between electromagnetic (EM) radiation and matter as a function of its frequency or wavelength. From this, a number of quantitative and qualitative measurements defining aspects like sample concentrations, structure, chemical compositions etc, can be obtained depending on the spectroscopic technique and spectrum of EM radiation…
laboratory safety rules
Lab BasicsLab Management
October 3, 2019

Laboratory Safety Rules and Guidelines

Preston Brown, a graduate student at Texas Tech University was working on the highly energetic nickel hydrazine perchlorate (NHP) in early January 2010 when an almost fatal accident that scarred him for life occurred. In a series of events that involved disregard for his supervisor’s guidelines, failure to wear safety…
Mastering the Microtome
Lab Basics
September 19, 2019

Mastering the Microtome

Description of Microtome Generally, microtomes are involved in the process of preparing samples of biological material to be examined under a microscope. Specifically, they slice material into extremely thin pieces so they can fit in a microscope slide and be studied by researchers. It holds the material in place while…