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SKU BB-BNP-32/ BB-BNP-48 Categories , Tags , , ,

Nucleic Acid Extraction System

See more by: Biobase

$6,600.00$11,650.00

10% off with your subscription Membership
Sku: BB-BNP-32/ BB-BNP-48 Categories , Tags , , ,
 / Availability: In Stock / Delivery Info ⓘ

Description

BB-BNP32/BB-BNP48 system is a fully-automated clinical nucleic acid extraction system that brings you walk-away automation, designed to minimize user intervention and extraction-to-extraction variability. In addition to providing quality purified eluates, the BNP32/BNP48 system offers onboard primary-sample handling and mixed-batch sampling for up to 32 or 48 samples per run.

Meet the producer

Producer: Biobase

Biobase is a global company specializing in laboratory equipment and biotechnology products. Founded in China, Biobase offers a wide range of products, including biosafety cabinets, laboratory refrigerators, centrifuges, and other essential laboratory instruments.

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Description

Specifications

Parameters

BB-BPN32

BB-BPN48

Sample Quantity

32

48

Processing Volume

60µl~1000µl

60µl~1000µl

Sample Volume

20~500µl

20~500µl

Sample Throughput

1~32

48

Magnetic Bead Recovery

>98%

>98%

Extracting the Difference Between Holes

CV≤3%

CV≤3%

Heating Temperature

8 independent heating modules, customize lysis and elution temperature(temperature range) according to your needs

8 independent heating modules, customize lysis and elution temperature(temperature range) according to your needs

Oscillating Mixing

Low, medium and high third gears are adjustable, and the fluctuation range can be adjusted with the reagent volume

Low, medium and high third gears are adjustable, and the fluctuation range can be adjusted with the reagent volume

Reagent Type

Magnetic bead open platform

Magnetic bead open platform

Extraction Time

8~60min/round(depending on the reagent used)

8~60min/round(depending on the reagent used)

Internal Program

48 groups

50000 groups

Program Management

Powerful program editing capabilities to meet different reagent needs U disk program import and export can be achieved

Powerful program editing capabilities to meet different reagent needs U disk program import and export can be achieved

Safety Door Design

After the safety door is opened, the program operation will be automatically suspended, and the program can continue t run after the safety door closed

After the safety door is opened, the program operation will be automatically suspended, and the program can continue t run after the safety door closed

Built-in Air Duct

Yes

Yes

Ultraviolet Irradiation

Yes

Yes

Packing Size(W*D*H)mm

580*510*700

700*520*750

Gross Weight(kg)

51

80

Features

  • High Efficiency and Throughput:
    • Process up to 32 (BNP32) or 48 (BNP48) samples simultaneously, maximizing productivity and reducing turnaround time.  
    • Rapid extraction capabilities, completing runs in as little as 8-60 minutes, depending on the reagent and protocol used. 
  • Intuitive Touchscreen Control:
    • Equipped with a responsive 7-inch touch screen for user-friendly operation and clear visualization of the extraction process.  
    • Simple navigation and real-time monitoring of parameters for enhanced control.
  • Precise Temperature Management:
    • 8 independent heating modules provide precise control over lysis and elution temperatures, crucial for optimizing extraction efficiency.
    • User-defined temperature settings allow for customization to specific reagent requirements and sample types.   
  • Flexible Programming:
    • Powerful programming capabilities enable the creation and storage of up to 50,000 protocols, accommodating a wide range of extraction needs.  
    • Open system architecture offers the flexibility to use various magnetic bead-based extraction kits and customize protocols. 
    • Convenient program import and export via USB drive for easy sharing and backup of protocols.  
  • Enhanced Safety and Contamination Control:
    • Integrated UV disinfection function with a user-adjustable timer (1-24 hours) to effectively minimize the risk of cross-contamination.  
    • Safety door design automatically pauses the operation when opened, protecting the user and preventing procedural interruptions. 
    • Built-in air duct system ensures proper ventilation and minimizes aerosol escape.  
  • Consistent and Reliable Performance:
    • High magnetic bead recovery rate (greater than 98%) ensures efficient and consistent nucleic acid isolation.   
    • Low inter-well variability (CV ≤ 3%) guarantees reproducible results and minimizes data dispersion.   
    • Automatic control system streamlines operation and reduces the potential for user error
       

Principle

“The Nucleic Acid Extraction Systems employ the principle of magnetic bead-based extraction for high-quality nucleic acid purification.

  1. Binding: Nucleic acids within the sample are selectively bound to the surface of magnetic beads under specific buffer conditions.

  2. Washing: Magnetic separation is used to immobilize the beads while contaminants (proteins, cell debris, etc.) are washed away through a series of buffer exchanges.

  3. Elution: Purified nucleic acids are then released (eluted) from the magnetic beads using an elution buffer, ready for downstream applications.

The automated system precisely controls the movement of magnetic beads and reagents, along with temperature and mixing, to ensure efficient and reproducible extraction.

Applications

  • Molecular Biology Research: Isolation of DNA and RNA for gene cloning, expression analysis, and other research applications.

  • Clinical Diagnostics: Preparation of nucleic acids from patient samples for infectious disease testing, genetic screening, and personalized medicine.

  • Genomics: Extraction of high-quality DNA for sequencing and genomic analysis.

  • Forensics: DNA extraction from biological evidence for identification purposes.

  • Pharmaceutical Research: Nucleic acid purification for drug discovery and development

     

Summary

  • Automated instruments are used for the extraction of nucleic acids (DNA and RNA) from samples, utilizing magnetic bead technology.

  • The instruments automate the nucleic acid extraction process, which includes the binding, washing, and elution steps.

  • A touch screen is incorporated for user operation, and programmable settings are provided for extraction protocols.

  • The instruments are designed to process multiple samples within a single run.

  • Features of the instruments include:

    • Temperature control for the cracking and elution phases.
    • Ultraviolet (UV) disinfection capability.
    • Programmable parameters to accommodate different extraction procedures.
    • A safety door mechanism.
  • The instruments are employed in laboratory settings for applications such as molecular biology, clinical diagnostics, and other procedures requiring purified nucleic acids.

References

  1. Azimi, S.M., Nixon, G., Ahern, J. et al. A magnetic bead-based DNA extraction and purification microfluidic device. Microfluid Nanofluid 11, 157–165 (2011). https://doi.org/10.1007/s10404-011-0782-9
  2. Melanie Störmer, Knut Kleesiek, Jens Dreier, High-Volume Extraction of Nucleic Acids by Magnetic Bead Technology for Ultrasensitive Detection of Bacteria in Blood Components, Clinical Chemistry, Volume 53, Issue 1, 1 January 2007, Pages 104–110, https://doi.org/10.1373/clinchem.2006.070987
  3. Smith K, Diggle MA, Clarke SC2003.Comparison of Commercial DNA Extraction Kits for Extraction of Bacterial Genomic DNA from Whole-Blood Samples. J Clin Microbiol41:.https://doi.org/10.1128/jcm.41.6.2440-2443.2003
  4. Farani PSG, Lopez J, Faier-Pereira A, Hasslocher-Moreno AM, Almeida IC, Moreira OC. Utility of Magnetic Bead-Based Automated DNA Extraction to Improve Chagas Disease Molecular Diagnosis. International Journal of Molecular Sciences. 2025; 26(3):937. https://doi.org/10.3390/ijms2603093

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