Spectrophotometer

Need a Spectrophotometer for your Lab? Click here The spectrophotometer is a common optical device that measures the intensity of light relative to color (or wavelength). In the lab, they are used to determine how much light is absorbed by a colored chemical dissolved in the solution. This allows us to calculate the concentration or […]

Weight Drop Injury Model

Introduction Traumatic brain injury (TBI) is one of the most common brain injuries caused by an external impact or pressure, such as rapid acceleration or deceleration, crushing, and projectile penetration. Following TBI, cognitive, physical, and psychosocial functions are impaired depending on the severity of the injury. To investigate TBI, several animal models of experimental traumatic […]

6-OHDA rat models

Parkinson’s disease (PD) is the most common neurological disorder that is characterized by debilitating motor abnormalities, including muscle rigidity, resting tumor, stiffer voluntary movements, and postural instability. Primary neuropathological condition of PD includes progressive degeneration of the dopaminergic neurons in the nigrostriatal area. Experimental models of PD are specifically designed to gain detailed insights into […]

Animal Models of Traumatic Brain Injury

Introduction The use of animal models for studying traumatic brain injury (TBI) has several advantages, including low breeding costs, easy maintenance, and innovative techniques to create genetically modified strains. Rodent models provide powerful tools to screen and characterize putative therapeutic targets in TBI. These models efficiently recapitulate several clinical features of TBI such as closed […]

Rodent Craniotomy Protocol

Introduction A craniotomy is a surgical procedure used to temporarily open a part of the skull to expose the brain for experimental manipulations. Research developments over the past two decades have made craniotomy safer, simpler, and more successful. In craniotomy, a bone flap is removed from the skull to reach the internal brain. Craniotomies are […]

Controlled Cortical Impact for Traumatic Brain Injury

Introduction Traumatic brain injury (TBI) is referred to as alteration or dysfunctionality in brain function, or brain pathology resulting from external trauma or force. TBI is a serious health condition because of its complexity and wide-reaching effects, including lesions, necrosis, and axon degeneration. Research on traumatic brain injury has been challenging because no two injuries […]

Fluid Percussion Injury

Need impactors for your experiments? Click here Introduction The fluid percussion injury (FPI) model is a widely used study model for traumatic brain injury. FPI model produces an injury through a craniectomy by applying a momentary fluid pressure pulse on to the exposed dura. This pulse is created by a pendulum striking to the piston […]

Huntington’s Disease Rodent Models

Introduction ]Huntington’s disease (HD) is an inherited genetic neurological disorder characterized by cognitive dysfunction, abnormal body movements, progressive cell death, and neurodegeneration of the striatum and cerebral cortex. HD is a dominantly inherited disorder caused by a genetic mutation in the IT15 gene. This mutation is an abnormally expanded and unstable CAG repeat within the […]

Parkinson’s Disease Rat Models

Introduction Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the loss of 50% to 70% of the dopaminergic neurons in the substantia nigra pars compacta (SNc), loss of dopamine (DA) in the striatum, and the development of intracytoplasmic inclusions called Lewy bodies (LB), composed of α-synuclein and ubiquitin. α-synuclein has an important role […]