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Small Animal MRI System

 

 

Our Small Animal MRI System is a permanent magnet system that provides high-contrast images and has an intuitive user interface.

The Small Animal MRI system is a low-field NMR (Nuclear Magnetic Resonance) apparatus. It is utilized for in-vivo MRI observation of small animals such as rodents. It has a wide range of applications in neurology, histology, and metabolism. The system provides high-contrast images using a powerful permanent magnet system with an intuitive user interface. Two models are available for small animal analysis. 

 

Apparatus and Equipment 

Two models of the apparatus are available, a 40H model and a 60H model. The 40H model measures 1800 mm in length, 800 mm in width, and 1200 mm in height. It has a total weight of 1.1 tons, of which the magnet weighs 1.0 tons, and the control cabinet weighs 0.1 tons. The 60H model measures 700 mm in length, 530 mm in width, and 514 mm in height. The control cabinet measures 560 mm in length, 660 mm in width, and 970 mm in height. It has a total weight of 800 kg, of which the magnet weighs 700 kg, and the control cabinet weighs 100 kg. 

It is equipped with a permanent magnet (1.0 ± 0.05T for the 40H model and 0.5±0.05T for the 60H model). The standard probe size for the 40H model is 40 mm, while the 60H model includes probe sizes of 60 mm and 40 mm with an optional 25 mm probe. It has a sensitivity volume of (Ø 40 mm× 40 mm). The 40H model magnet uniformity is 20 ppm (40mm×40mm×40 mm), while the 60H model magnet uniformity is ≤20ppm (60mm×60mm×60mm). The effective detection size of the 40 mm probe for the 40H model is up to Ø 40 mm. The 60H model’s effective detection size for the 60 mm probe is up to Ø 62mm (45 – 150 g mice), the 40 mm probe is up to Ø 42mm (20 – 45 g mice), and the 25 mm probe is up to Ø 32mm (1 – 20 g mice). The 40H model MRI gradient is > 7.5 Gauss/cm doe x, y, z, and the 60H model MRI gradient is > 5 Gauss/cm for x, y, and z. 

The magnet’s field stability is ≤300Hz/Hour. The magnet has a dual system of nonlinear precise temperature control. The temperature is tunable from 25℃ to 35℃ with a temperature accuracy of ±0.1℃. . The RF field pulse is within the range of 1-30MHz with a frequency control accuracy of 0.1 Hz. The RF power multiplier is > 300W. The maximum bandwidth is 2000KHz. The image quality is graphic SNR >= 20db; Image distortion ≤ 5%; Image uniformity >=70%. The maximum data record length is 18000 CPMG. The minimum echo time is 200 US. 

 

Components 

The following components are included with the apparatus 

  1. The Magnet unit includes the magnet, magnet unit box, and gradient coil.
  2. The Control cabinet includes
    1. The RF unit comprises the RF unit box, RF power amplifier, and preamplifier.
    2. The spectrometer unit with the industrial control computer, time control, pulse sequence generator, direct digital frequency Synthesis, digital-to-analog converter, and analog-to-digital converter. 
    3. The power supply unit comprises a magnet temperature control, heating system, and power supply system. 
    4. The imaging gradient unit comprises a gradient unit box and a gradient power amplifier. 
  3. Probe coils, including 70 mm and 40 mm probe coils.
  4. The apparatus also includes a Magnetic Resonance Imaging System Software and an NMR Analyzing System Software. 
  5. The following accessories are included with the system 
    1. Niumag Software USB
    2. Fuses
    3. Debugging tools including special tools, 50Ω terminal, BNC adapter assembly, and testing line
    4. Computer peripherals include an LCD display and a mouse and keyboard. 

 

Applications 

The Small Animal MRI System has several applications in the following fields 

  • Oncogenic research – can be used to screen for tumor lesion location; tumor size measurement; and in the evaluation of drug treatment of cancer.
  • Contrast Agents (CAs) Characterization –  it can be used for relaxation analysis of T1, T2, and T1-T2 evaluation of CAs imaging behavior both in-vivo and in-vitro and for monitoring metabolism of CAs in-vivo
  • Pharmacological Research – it can be used to evaluate the performance and metabolism of nano-drug carriers in vivo and to determine the targeting properties of specific agents. 
  • Disease Mode Study of Diabetes and Obesity and Cardiovascular Disease.

 

Literature Review 

Analysis of In Vivo Hepatic Steatosis 

Cui, Hu, Han, Yang, and Li (2017) utilized the Small Animal MRI System to analyze the body composition of mice to study hepatic steatosis. Eight-week-old male C57BL/6 mice were fed a high-fat and high-sucrose diet for four to sixteen weeks. This was done to induce obesity in the mice, which is one of the key risk factors of nonalcoholic fatty liver disease (NAFLD) of which Hepatic steatosis is the earliest stage of NAFLD. The Small Animal MRI System measured the body fat mass, lean mass, and fluids of the mice. The whole body of the mice and their livers were scanned using a 0.55 T magnet with the device. The results indicated that the subjects’ body weight increased to 45±1.2 g after 16 weeks of feeding on the high-fat, high-sucrose diet. Overall results from the MRI analysis indicated that hepatic steatosis and obesity increased with the high-fat and high-sucrose diet. 

 

Investigation of the effect of myricetin in activating brown adipose tissue for preventing obesity and insulin resistance in mice 

Hu et al. (2017) investigated the effect of myricetin in brown adipose tissue (BAT) activation in preventing obesity and insulin resistance in DB/DB mice. Leptin receptor-deficient DB/DB male mice were given myricetin (400 mg/kg) in distilled water daily by oral gavage starting at 4 weeks old for 14 weeks. The subjects’ body weight, blood lipid profile, glucose intolerance test, and BAT activation were assessed using PET-CT. The Small Animal MRI System was used to analyze the subjects’ body composition at 18 weeks of age. The results indicated lower weight gain in the myricetin-treated DB/DB mice compared to the control mice. The total body fat mass of the myricetin-treated mice also decreased by ~27% compared to controls. The PET-CT results indicated that myricetin activated BAT in DB/DB mice where 18FFDG absorption of BAT within the dashed triangle was around three times higher in treated mice compared to untreated mice. Therefore, overall results revealed that myricetin inhibits systemic insulin resistance and reduces obesity by activating BAT.

Strengths 

The Small Animal MRI System has a permanent tesla magnet that provides high magnetic field uniformity and minimal eddy current effect. The system allows high-quality anatomy imaging with a high resolution of < 0.08 mm. The MRI software is user-friendly. It includes multiple sequences for full MRI capabilities. The system is non-destructive, with no risk or negligible running costs since it doesn’t require cryogenic gases. Two models of the system are available to suit your experimental needs. The system can be used for several applications in several life science fields, including oncogenic research, pharmacological research, and studying obesity and cardiovascular disease models.  

Summary 
  • The Small Animal MRI system is a low-field NMR (Nuclear Magnetic Resonance) apparatus utilized for in-vivo MRI observation of small animals such as rodents. 
  • It provides high-contrast images using a powerful permanent magnet system with an initiative use interface
  • It is available in two models, a 40H model and a 60H model, to suit your experimental needs.
  • The system also includes a Magnetic Resonance Imaging System Software and an NMR Analyzing System Software. 
  • It has a wide range of applications in neurology, histology, and metabolism. 
Reference
  1. Cui, A., Hu, Z., Han, Y., Yang, Y., & Li, Y. (2017). Optimized Analysis of In Vivo and In Vitro Hepatic SteatosisJournal of visualized experiments: JoVE, (121), 55178. https://doi.org/10.3791/55178
  2. Hu, T., Yuan, X., Wei, G., Luo, H., Lee, H. J., & Jin, W. (2018). Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db miceEuropean journal of nutrition57(1), 391–403. https://doi.org/10.1007/s00394-017-1433-z
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