The Standard Manual Stereotaxic Instrument is important equipment in the fields of neuroanatomy, neurophysiology, neuropharmacology, and neurosurgery. It uses the marks on the surface of the skull (such as the bregma point) as the basic reference point to determine a certain subcortical layer of the animal through three-dimensional movement. The location of the nerve structure (nucleus), and then complete the directional injection, stimulation, destruction, guidance, and positioning of the nerve structure. It can be used to establish animal models of Parkinson’s disease, animal models of epilepsy, brain tumor models, and learning, research on memory, neural stem cell transplantation in the brain, cerebral ischemia, etc. This is the Manual version of the Digital Stereotaxic Instrument for Rat.
Open Field test is a popular protocol used to assess exploratory behavior and anxiety. Thigmotaxis in the open field is used to evaluate anxiolytic, anxiogenic and even non-pharmacological treatments. Ambulation is the most common behavior studied with this maze, but others such as latency or rearing can also be measured. In addition, objects can be added for a modification similar to the novel object recognition field.
Walls can be both opaque or clear. We recommend that clear walls are used for measurements of anxiety, while opaque walls are used if assessments include novel object recognition.