Active Place Avoidance

SKU ME-APA-6003
$13,990.00
Unit: Each
IncludesStandard Care

Rotating arena system for assessing spatial navigation and avoidance learning in rodents through continuous platform rotation and room cue-defined shock zones.

Species SKU ME-APA-6003
$13,990.00
Unit: Each
Scientist guidance
Louise Corscadden, PhD, Director of Science

Louise Corscadden, PhD

Director of Science · ConductScience

Ask Louise about Active Place Avoidance fit, setup, configuration, or quote prep.

Used in a 2026 paper in the journal Cell

The paper found that a liver enzyme linked to exercise reversed memory loss in old mice and in Alzheimer’s model mice by acting on brain blood vessels.

Featured in an NIH research highlight.

From the methods
The mice were placed in a rotating cylindrical arena (Maze Engineers; 1 meter in diameter, rotation speed at 1 rotation/minute) and had to learn to avoid a stationary 60° area (shock zone) using visual cues placed around the arena.

Maze Engineers, the maker named in the paper, is part of ConductScience.

See all 2 papers citing this product

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Key Specifications

Full details →
Model fit
Mouse, Rat
SKU family
CS-958422
Sizing
Mouse: Diameter 78 cm · Height 35 cm; Rat: Diameter 105 cm · Height 35 cm
Ordering
Online checkout and quote request available
Category
Behavioral Mazes
Build notes
Confirm accessories, station layout, and support needs before purchase
Category: Behavioral Mazes

Score this test with ConductVision

ConductVision is our video-tracking software. Record your sessions on video, and it reports the measures listed below.

What it measures

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The Advanced Rodent Module runs on this license. On its own, the license scores standard tests such as the open field, the elevated plus maze, the Y-maze and the Morris water maze. Results export as CSV files.

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§ 1

Introduction

The Active Place Avoidance is a avoidance assay built around spatial avoidance learning, conflict between room and arena cues, and memory flexibility. Interpretable data depend on matching the apparatus geometry, subject species, trial structure, and scoring rules to the behavioral construct under study. 1

Spatial avoidance protocols depend on stable geometry, consistent trial timing, and pre-defined scoring rules. Without those controls, avoidance time can be shifted by motivation, locomotion, light level, odor, cue salience, or handling rather than the intended behavioral construct. 1

This methods section summarizes setup, endpoint definitions, common confounds, sample output, adjacent assays, and reporting details needed to evaluate Active Place Avoidance results alongside the product specifications. 1

§ 2

Methods

2.1 Procedure

Spatial avoidance with standardized setup, trial timing, and endpoint extraction.

Pre-test setup

  1. 1.Define construct: Pre-register whether the study uses Active Place Avoidance for avoidance behavior, screening, cohort comparison, or apparatus validation.
  2. 2.Calibrate apparatus: Verify rotating arena or place-avoidance platform with stationary shock zone, visibility, lighting, surface condition, cue placement, and camera field of view before animals enter the room.
  3. 3.Set scoring rules: Define avoidance time, omissions, exclusions, latency cutoffs, and event thresholds before acquisition starts.
  4. 4.Control carryover: Use consistent cleaning, handling, acclimation, and inter-trial timing so odor, stress, and fatigue do not become hidden treatment variables.

Trial sequence

  1. 1.Start trial: Place the subject at the protocol-defined start location and begin synchronized video or event logging.
  2. 2.Record behavior: Capture avoidance time, path order, latency, dwell time, and relevant zone or arm events throughout the trial.1
  3. 3.Apply endpoint rules: Score only committed entries or events that meet the pre-defined body-position and timing criteria.
  4. 4.End and reset: Stop at the maximum duration, completion criterion, or humane endpoint, then clean and reset the apparatus.
  5. 5.Export QC: Review tracking loss, outlier latency, immobility, omissions, and apparatus notes before group-level analysis.

Critical methodological constraints

  • Shock sensitivity. Document shock sensitivity because it can shift avoidance time independent of the intended construct.
  • Locomotor activity. Keep locomotor activity stable across cohorts and sessions.
  • Cue stability. Audit cue stability before interpreting group differences.
  • Arena rotation. Report arena rotation when it changes engagement, exploration, or measurable trial completion.
  • Stress reactivity. Flag stress reactivity during QA because it often explains apparent assay failure.2

2.2 Measurement & Analysis

Core Active Place Avoidance endpoints for behavioral interpretation and apparatus quality control.

Avoidance time

Spatial avoidance learning

Avoidance time is the primary endpoint for this page and should be paired with latency and quality-control flags.1

First-entry latency

Latency and initiation

First-entry latency helps distinguish task performance from motivation, freezing, fatigue, or handling effects.

Shock-zone entries

Spatial or zone strategy

Shock-zone entries captures how the subject solved the task, not only whether it reached the endpoint.

Distance traveled

Engagement control

Distance traveled identifies omissions, low exploration, sensor dropouts, or species-specific non-response.

Cue-frame mismatch

Quality-control flag

Cue-frame mismatch should be reviewed before exporting final group summaries.

+ Additional metrics: trial duration, zone dwell, event count, path efficiency, tracking confidence, exclusions, and session-level notes.

2.3 avoidance time ratio (analysis)

A compact percentage summary for Active Place Avoidance output.

Inline calculator

Type the values your tracker recorded.

Full calculator with 95% CI ->
Avoidance time ratio

86.7%

Formula: avoidance time / (avoidance time + shock-zone time) x 100. Interpret with latency, engagement, and confound checks before making construct-level claims. 1

§ 3

Results

3.1 Sample apparatus output

Representative Active Place Avoidance output for methods review and endpoint interpretation.

Table 1 · Per-animal Active Place Avoidance scoring output

AnimalGroupAvoidance timeFirst-entry latencyShock-zone entriesSummary
APA-001Control274 s88 s287.3%
APA-002Control261 s79 s386.1%
APA-003Impaired188 s31 s962.7%
APA-004Impaired176 s28 s1158.7%

Synthetic example for illustration only. Replace with tracked output screenshots or exported data when product media are available.

§ 4

Discussion

Limitations of the paradigm, methodological caveats, and current directions.

4.1 Common confounds

Variables that can shift Active Place Avoidance results apart from the effect under study.

Shock sensitivity

Shock sensitivity can change apparent Active Place Avoidance performance without reflecting the intended behavioral construct.

Locomotor activity

Locomotor activity can change apparent Active Place Avoidance performance without reflecting the intended behavioral construct.

Cue stability

Cue stability can change apparent Active Place Avoidance performance without reflecting the intended behavioral construct.

Arena rotation

Arena rotation can change apparent Active Place Avoidance performance without reflecting the intended behavioral construct.

Stress reactivity

Stress reactivity can change apparent Active Place Avoidance performance without reflecting the intended behavioral construct.

4.2 Construct validity caveats

Active Place Avoidance is strongest when endpoint definitions, apparatus settings, and exclusion rules are specified before testing. Treat a single summary metric as a screening signal, then confirm interpretation with latency, engagement, comparator assays, and quality-control review. 1

4.3 Special considerations

When should I choose Active Place Avoidance?

Choose Active Place Avoidance when the research question matches spatial avoidance learning, conflict between room and arena cues, and memory flexibility. and the lab can control shock sensitivity, locomotor activity, and trial timing.

What setup variables should be specified before testing?

Specify species, cohort size, apparatus dimensions, lighting, tracking method, automation level, cleaning workflow, endpoint definitions, and exclusion criteria before data collection begins.

What makes the data interpretable?

Interpretation is strongest when the apparatus configuration, trial timing, scoring thresholds, confound controls, and comparator assays are documented together with the primary endpoint.

4.4 Current directions

Quarterly editorial review of emerging Active Place Avoidance methodology. Q2 2026

Methods

Endpoint standardization

Define avoidance time, latency, exclusions, and engagement flags before comparing cohorts.

Emerging

Automated scoring

Camera and event-log workflows can reduce observer burden and improve consistency when zone definitions and event thresholds are validated.

Methods

Comparator batteries

Active Place Avoidance should link to adjacent maze, motor, or motivation assays when interpretation depends on controls.

Emerging

Integrated method reporting

Apparatus dimensions, protocol fit, tracking compatibility, and endpoint definitions should be reported together so results are easier to reproduce.

§ 5

Background references

10 selected methods and validation studies of the Active Place Avoidance, from any lab.

  1. Dudchenko PA. An overview of the tasks used to test working memory in rodents. Neurosci Biobehav Rev. 2004;28(7):699-709. doi:10.1016/j.neubiorev.2004.09.002
  2. Shoji H, et al. Comprehensive behavioral test battery for mice. Curr Protoc Mouse Biol. 2012;2:153-187. Find source
  3. Vorhees CV, Williams MT. Assessing spatial learning and memory in rodents. ILAR J. 2014;55(2):310-332. Find source
  4. Lalonde R. The neurobiological basis of spontaneous alternation. Neurosci Biobehav Rev. 2002;26(1):91-104. doi:10.1016/S0149-7634(01)00041-0
  5. Walf AA, Frye CA. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc. 2007;2(2):322-328. doi:10.1038/nprot.2007.44
  6. Pellow S, Chopin P, File SE, Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 1985;14(3):149-167. doi:10.1016/0165-0270(85)90031-7
  7. Crawley JN, Goodwin FK. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav. 1980;13(2):167-170. doi:10.1016/0091-3057(80)90067-2
  8. File SE, Wardill AG. Validity of head-dipping as a measure of exploration in a modified hole-board. Psychopharmacologia. 1975;44(1):53-59. Find source
  9. Walsh RN, Cummins RA. The Open-Field Test: a critical review. Psychol Bull. 1976;83(3):482-504. doi:10.1037/0033-2909.83.3.482
  10. Brown RE, Corey SC, Moore AK. Differences in measures of exploration and fear in MHC-congenic C57BL/6J and B6-H-2K mice. Behav Genet. 1999;29(4):263-271. Find source
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