Principle, Types, and Applications of Patch Clamp Electrophysiology

Patch clamp electrophysiology is an experimental technique that reads into electrical events in cells. The electric potential between the cell membrane reveals the workings of cell membranes and ion channels, a group of proteins that detect and control the movement of ions in and out of the cells.[1] The technique was developed through a collaboration […]

Types and Applications of Imaging Chambers

Introduction Cells are building blocks of organisms. Thus, understanding the whole metabolic processes and dynamics of organisms requires us to look clearly inside cells. Advanced microscopy technologies combined with protein labeling approaches have enabled scientists to understand cellular processes and investigate the dynamic processes in organisms with better resolution and sensitivity.[1] The quality optical conditions […]

Ultimate Guide to Slice Cultures, Types, and Their Relevance

Tissue slices represent the organs or intact tissue for in vitro studies such as biochemical analyses, live-cell imaging, electro-physiological, and pharmacological studies. Theoretically, tissue slices are short-lived and should be used immediately. In practice, tissue slices can be temporarily maintained in cold storage or cryopreserved to reduce or stop their metabolic activities, thus extending their […]

Ultimate Guide on Neuronal or Brain Slice Electrophysiology

What is Brain Slice? Electrophysiology refers to studying the electrical properties of biological cells and tissues. Thus, brain or neuronal electrophysiology pertains to a branch of electrophysiology that deals with measuring electric current or voltage changes in one neuronal cell, a brain slice, or the whole brain. The methodology was first introduced by Yamamoto and […]

What Is A Brain Slice? Everything To Know About A Brain Slice

Introduction Today, we all — biologists or not — have an idea about how the brain functions. The advanced techniques and lab procedures have made the knowledge accessible and unlocked many mysteries related to brain functioning. One such procedure is brain slicing. It’s a process in which parts of the brain are divided using advanced […]

Types of Tissue Slice Techniques for Slice Preparation

Tissue slices are sections of tissue cut from larger pieces or extracted organs and treated in a medium to gain insights into the working of the originating tissue or organ. Unlike sections for histological studies, tissue slices for metabolic studies are not fixed and preserved. Rather, they are prepared immediately after the excision or after […]

Electrophysiology Chambers: How To Examine Tissue Slices

What Are Electrophysiology Chambers? Electrophysiology chambers are designed to study tissue electrophysiology in preclinical research. These chambers can be used for tissue slices in neuropharmacological and toxicological animal models in preclinical research, especially in rodents like rats and guinea pigs. Electrophysiological recordings can be taken simultaneously from tissue slices using electrophysiology chambers, which allows researchers […]

Cardiac Electrophysiology: How to Setup a Cardiac Electrophysiology Lab

Are you looking for Slice Electrophysiology devices for your lab? Click here Electrophysiology Lab: Definition Electrophysiology labs are centers that provide care for people having arrhythmias (heart rhythm disorders) or neural disorders.[1] Thus, the lab is split into cardiac electrophysiology and neural electrophysiology labs. Electrophysiology labs perform electrophysiology studies. In a heart condition, the heart’s […]

Mastering the Microtome

Need Microtomes for your studies? Click here Description of Microtome Generally, microtomes are involved in the process of preparing samples of biological material to be examined under a microscope. Specifically, they slice material into extremely thin pieces so they can fit in a microscope slide and be studied by researchers. It holds the material in […]